摘要
本文合成了四氢叶酸模型化合物。碘化1,2-二甲基-3-对甲氧苯磺酰基咪唑啉,模拟四氢叶酸甲酸氧化态的一碳单元转移,成功地把次乙基转移给邻苯二氨、邻氨基苯酚,邻氨基苯硫酚,证明此甲酸态的模型是一个很理想的转移体化合物。
1, 2-dimethy L-3-(p-methoxybenzenesulfonyl) imidazolinium iodide, which serves as tetrahydrofolate models in terms of their ability to transfer the methenyl to 1. 2-di-aminobenzene 12-aminbphenol, 2-aminobenzenethial,has been synthesized, It is successful to imitate one-carbon unit transfer of tetyahydrofolate at the formyl level, which has proved that the models at the formyl level is a potential donors.
基金
国家自然科学基金
山西省自然科学基金
归国人员基金