急性心肌梗塞患者血浆内皮素-1浓度的动态变化

Dynamic changes of plasma concentrations of endothelin-1 in patients with acute myocardial infarction

对急性心肌梗塞（AMI）患者按是否并发梗塞后心绞痛、梗塞延展和心力衰竭分为24倒无并发症组和11例有并发症组，采用放射免疫方法检测不同时间血浆内皮素－1（ET－1）浓度。结果显示：与正常对照组（1．60±0．43pg／ml）比较，无并发症组和有并发症组AMI患者血浆ET－1浓度在入院即刻已经升高（2．70±0．46pg／ml和2．98±0．50pg／ml，均P＜0．01），无并发症组到发病后第3天降低到正常（1．82±37pg／ml．P＞0．05）．而有并发症组一直持续到观察终点第7天仍然比较高（3．60±0．41pg／ml，P＜0.01）。提示：AMI患者血浆ET－1浓度持续升高反映了心肌持续缺血或心功能减退。

To observe dynamically the changes in plasma concentrations of ET-1 in patients with acute myocardial infarction (AMI ), concentrations of ET-1 were measured by radioimmunoassay from 35 cases of AMI (11 patients with postinfarct angina,infarct extension or heart failure. [complicated group] and 24 patients with uncomplicated infarction [uncomplicated group ]) and 20 cases of the control subjects (control group). The results showed that concentrations of ET-1 in the complicated group were significantly higher already on admission and remained significantly higher untill day 7 after AMI than those in the control group (P<0.001,respectively),and concentrations of ET-1 in the uncomplicated group were significantly higher on admission (P<0. 001 )than those in the control group and returned toward the normal range by day 3 after AMI. These dates indicated that the sustained increase in plasma ET-1 in AMI with complication reflected continuing ischemia or marked depression in ventricular function.