不同药物对糖尿病骨质疏松的短期疗效比较

Effect of different drugs on diabetic osteoporosis

把糖尿病合并骨质疏松而血糖控制满意的患者分为单纯加用钙剂组（组１）、钙剂加维生素Ｄ２组（组２）、钙剂加罗钙全组（组３）、钙剂加密钙息组（组４）及单纯糖尿病治疗组为对照组（组５），治疗三个月后进行疗效比较。结果组１、组５治疗前后骨密度、骨代谢指标（血钙、血磷、碱性磷酸酶（ＡＫＰ）、血甲状旁腺激素（ＰＴＨ）、尿羟脯氨酸）均无明显变化（Ｐ＞０．０５）。组２治疗后ＰＴＨ明显降低（Ｐ＜０．０５）。组３、组４血ＰＴＨ、ＡＫＰ均明显降低（Ｐ＜０．０５）。提示糖尿病骨质疏松单纯应用钙剂近期效果不明显，需加用维生素Ｄ２、降钙素或罗钙全治疗才有效，而以同时加用降钙素或罗钙全者效果更明显。

Osteoporosis is a common complication in diabetic patients.In this paper,the patients complicated with diabetic osteoporosis and satisfied blood glucose control were divided into five groups.Group l calcium administration alone,Group 2 calcium plus vitamin D_2 Group 3 calcium plus rocaltrol,Group 4 calcium plus miacalcic,Group 5 control.After three months of treatment,there is no significance change of bone mineral density,serum calcium,serum phosphate,alkaline phosphatase,serum parathyroid hormone and urine hydroxyproline in G_1 and G_5(P>0.05).There were significant decrease of PTH in G_2(P<0.05),of PTH and AKP in G_ 3and G_4(P<0.05),The results showed that only calcium administration has little effect,it would be better to add vitamin D_2,calcium plus calcitonin or rocaltrol may sive more significant effect.