牛磺酸对白细胞介素－1β损伤的胰岛细胞分泌的影响

The influence of taurine on IL-1βinduced inhibition of insulin release from rat pancreaticislet cells

在Ｗｉｓｔａｒ新生大鼠离体培养胰岛细胞中定量观察了ＩＬ－１β对胰岛素分泌的抑制作用以及牛磺酸的反转效应。实验结果表明：①ＩＬ－１β（５～２０Ｕ／ｍｌ）可抑制胰岛β细胞的分泌功能，表现为胰岛素的基础分泌和葡萄糖刺激时的分泌量均明显减少。②经ＩＬ－１β处理的胰岛细胞加入牛磺酸共同孵育后，可见胰岛素的基础分泌量和糖刺激时的分泌量均显著增加，表明牛磺酸能反转ＩＬ－１β的抑制作用，并且这种反转效应有量效和时效关系。

The effect of taurine on IL-1βinduced inhibition of insulin release was investigated with cultured neonatal rat pancreatic islet cells.The results indicated that:①Insulin release, both the basal and glucose-stimulated,could be significantly inhibited by addition of IL-1β(5～20U/ml).②The inhibitory effect of IL-1β on insulin release could be reversed by taurine and this effect was directly related to the dose and action time of taurine.