哮喘患儿支气管诱导痰液中炎细胞变化的临床研究

The changes of inflammatory cells in bronchial induced sputum in asthmastic children

目的研究支气管哮喘患儿急性发作期及其缓解期支气管诱导痰液中炎细胞变化及临床意义。方法选择2002-02—2002-12在中国医大二院儿童哮喘门诊就诊的哮喘患儿,其中哮喘急性发作期34例;哮喘缓解期30例;健康对照组22例。比较哮喘不同病程之间以及不同病程与正常儿童之间支气管诱导痰液细胞成分的差异。结果哮喘患儿急性发作期支气管诱导痰液中,中性粒细胞占细胞总数的百分比明显高于缓解期及正常对照组(均P<0.01)。哮喘急性发作期、缓解期诱导痰液中嗜酸细胞占总数的百分比均明显高于正常对照组,差异显著(P<0.01)。结论支气管哮喘是一种慢性气道炎症性疾病,在不同发病时期气道内的炎细胞变化不同。

Objective To investigate the changes of inflammatory cells in bronchial induced sputum in children with bronchial asthma. Methods In children with bronchial asthma and normal volunteers by way of hypertonie saline inhalation challenge,34 patients in the acute episode and 30 in remission. Twenty-two volunteers were detected as normal control. Compare the differential cell counts in bronchial induced sputum. Results The percentage of neutrophils in bronchial induced sputum was significantly higher in the acute episode group in asthmatic children than that in remission period group （ P 〈0. 01 ） and in normal control （ P 〈0. 01 ） ;The percentage of eosinophils in induced sputum was significantly higher in the acute episode group and in remission period group of asthmatic children than that in normal control （ P 〈 0. 01 ）. Conclusion Bronchial asthma is a chronic airway inflammatory illness. There are differential cell counts in bronchial induced sputum in the different stage of illness.