血塞通与低分子肝素钙治疗不稳定型心绞痛疗效观察

STUDY ON UNSTABLE ANGINA PECTORIS TREATED BY XUESAITONG AND LOW MOLECULAR WEIGHT HEPARIN CALCIUM

目的：探讨血塞通与低分子肝素钙治疗不稳定型心绞痛(UAP)临床疗效。方法：将115例UAP患者随机分为对照组和治疗组。对照组56例用硝酸酯类、β-阻滞剂或钙拮抗剂治疗；治疗组59例加用血塞通注射液200mg/d与低分子肝素钙5000 U腹壁皮下注射q12h,主要观察心绞痛发作次数、平均持续时间、心电图变化、血液流变学指标,并进行分析对比。结果：治疗10d后,治疗组心绞痛缓解总有效率94．9%,其中显效35例(59．3%),有效21例(35．6%),无效3例(5．1%),两组间比较P＜0．01。心电图总改善率84．7%。结论：在常规心绞痛治疗的基础上联用血塞通与低分子肝素钙能有效地缓解心绞痛的症状,改善心电图及血液流变学指标。

OBJECTIVE： To explore the therapeutic effect of Xuesaitong and low molecular weight heparin calcium in treating unstable angina pectoris （UAP） , METHODS： 115 patients with UAP were divided into two groups at random. 56 patients in control group were treated by ester nitrate, β - receptor blocking agents or calcium antagonists. Except for the above therapy, Xuesaitong Zhusheye （200mg per day by intravenous drip） and low molecular weight Heparin calcium （5000u every 12 hours by subcutaneous injection on abdomen wall） Were added to 59 patients in the experimental group. Frequency and duration of Angina episode, ECG varies, blood rheology were recorded. RESULTS： After ten day treatment, symptoms in 94. 9% patients in the experimental group remitted, among which 35 patients （59. 3 % ） showed remarkable improvement; 21 patients （35.6%） certain improvement and 3 patients （5. 1% ） no improvement. The difference between the two groups was significant （P 〈0.01 ） . 84.7% symptom improvement could be reflected by ECG. CONCLUSIONS： based on regular therapy, the administration of Xuesaitong and low molecular weight heparin calcium can effectively improve symptoms of UAP and the results of ECG and blood rheology in patients with UAP.