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解偶联蛋白对动物能量代谢的作用 被引量:1

The Role of Uncoupling Proteins in Animal Energy Metabolism
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摘要 生物体内能量平衡问题始终是营养学研究的主要内容。已知影响生物体内能量平衡的因素很多,由解偶联蛋白(uncoupling proteins,UCPs)调控能量诱发脂肪组织和肌肉组织的生热作用是影响机体能量平衡的重要因素之一。本文综述了近年来UCPs的研究进展,着重论述了UCPs产热机制及其基因表达的影响因素,为深入开展UCPs能量代谢调控方面的研究奠定基础。 The energy balance in organic body has always been the major studying field in nutrition research. It is well known that the energy balance in organic body can be caused by many factors. Uncoupling proteins (UCPs), regulating diet-induced adipose tissues and muscular thermogenesis, are one of the important factors affecting the body energy balance. This paper gives a review of the research on UCPs in recent years, focusing mainly on the mechanism of thermogenesis and on the affecting factors in gene expression. It provides a foundation for further research on UCPs in regulating energy metabolism. [Chinese Journal of Animal Nutrition, 2006,18(Suppl) ..310-3151
出处 《动物营养学报》 CAS CSCD 北大核心 2006年第B12期310-315,共6页 CHINESE JOURNAL OF ANIMAL NUTRITION
基金 863计划资助项目(2003AA243046) 973计划资助项目(2004CB117507)
关键词 UCPs MRNA 基因表达 能量代谢 Uncoupling proteins mRNA Gene expression Energy metabolism
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参考文献36

  • 1Enerback S, Jacobsson A, Simpson E M, Guerra C,Yamashita H, Harper E, Kozak L P. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature, 1997, 387: 90-94.
  • 2Gura T. Uncoupling proteins provide new clue to obesity's causes. Science, 1998, 280 (5368):1369-1370.
  • 3Ricquier D, Bouillaud F. The mitochondrial uncoupling protein: structural and genetic studies. Progress in Nucleic Acid Research and Molecular Biology, 1997, 56:83 - 108.
  • 4Berger A, Brand M, Rahilly S. Uncoupling proteins the unravelling of obesity? Increased understanding of mechanisms may lead, in time, to better drugs. British Medical Journal, 1998, 317 (7173):1607- 1608.
  • 5郑文建,肖南,陆松敏.解偶联蛋白及其在基础代谢中的作用[J].国外医学(生理病理科学与临床分册),2002,22(4):418-420. 被引量:3
  • 6Yu X X, Mao W, Zhong A, Schow P, Brush J,Sherwood S W, Adams S H, Pan G, Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. Faseb Journal,2000, 14(11):1611- 1618.
  • 7Jezek P, Borecky J. Mitochondrial uncoupling protein may participate in futile cycling of pyruvate and other monocarboxylates. American Journal of Physics, 1998, 275:496-504.
  • 8Gong D W, Monemdjou S, Gavrilova O, Leon L R,Marcus-Samuels B, Chou C J, Everett C, Kozak LP, Li C, Deng C, Harper M E, Reitman M L. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3.Journal of Biological Chemistry, 2000, 275:16251 -16257.
  • 9Vidal-Puig A J, Grujic D, Zhang C Y, Hagen T,Boss O, Ido Y, Szczepanik A, Wade J, Mootha V,Cortright R, Muoio D M, Lowell B B. Energy metabolism in uncoupling protein 3 gene knockout mice, Journal of Biological Chemistry, 2000, 275:16258- 16266.
  • 10Cline G W, Vidal-Puig A J, Dufour S, Cadman KS, Lowell B B, Shulman G I, In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism. Journal of Biological Chemistry,2001, 276:20240 - 20244.

二级参考文献22

  • 1Gimeno RE,Dembski M,Weng X, et al. Cloning and characterization of an uncoupling protein homolog[J]. Diabetes, 1997, 46:900-906.
  • 2Garlid KD, Jaburek M, Jezek P, et al. How do uncoupling proteins uncoupl[J]? Biochem Biophys Acta, 2000, 1459(2-3) :383 - 389.
  • 3Jezek P, Hanus J, Semrad C, et al. Photiactived azido fatty acid irreversibly inhibits anion and proton transport through the mitochondrial uncoupling proton[J]. J Biol Chem, 1996, 271(11):6199-6205.
  • 4Winkler E, Wachter E, Klingenberg M. Identification of the pH sensor for nucleotide binding in the uncoupling protein from brown adipose tissue [J]. Biochemistry, 1997, 37:3-8.
  • 5Silva JE, Rabelo R. Regulation of the uncoupling protein gene expression[J]. Eur J Endocrinol, 1997,6:1887.
  • 6Fleury C, Neverova M, Collins S, et al. Uncoupling protein 2: a novel gene linked to obesity and hyperinsulinemia[J]. Nat Genet, 1997,15:269-272.
  • 7Hoffstedt J,Folkesson R, Wahrenberg H, et al. A marked upregulation of uncoupling protein 2 gene expression in adipose of hyperthyroid subjects[J]. Horm Metab Res, 2000, 22(11 - 12):475-479.
  • 8Scarpace PJ,Matheny M,Pollock BH, et al. Leptin increases uncoupling protein expression and energy expenditure[J]. Am J Physiol, 1997, 273(Endocrinol Metab 36) :E226-E230.
  • 9Cortez-Pinto H, Yang SQ, Lin HZ, et al. Bacterial lipopolysaocharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-α-dependent mechanism [J]. Biochem Biophys Res Commun,1998, 251:313 - 319.
  • 10Gong DW, He YF, Kaeas M, et al. Uncoupling protein 3 is a mediator of thermogenesis regulated by thyroid hormone, (3-adrenergic agonists and leptin[J]. J Biol Chem, 1997,272:24129-24132.

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