杏丁注射液对肾病综合征患者血液流变学影响的研究

Study of the effect of Xingding injection on hemorheology in patients with primary nephritic syndrome

目的探讨杏丁注射液对原发性肾病综合征(PNS)患者血液流变学的影响。方法将86例PNS患者随机分为2组,均给予泼尼松治疗。治疗组加用杏丁注射液,对照组加用肠溶阿司匹林和潘生丁。治疗前后检测24 h尿蛋白定量、血浆白蛋白、血肌酐、内生肌酐清除率及血液流变学指标。结果2组治疗后血浆白蛋白及24 h尿蛋白定量均显著改善,而血肌酐、内生肌酐清除率均无明显变化。治疗组治疗后的血液流变学指标除血小板聚集率和血沉外,与对照组相比均有显著性差异。结论杏丁注射液改善PNS血液流变学异常效果肯定,安全可靠。

Objective It is to explore the influence of Xingding injection on hemorheology in patients with primary nephritic syndrome （PNS）. Methods 86 cases of PNS patients were divided randomly into control group and treatment group, and both were treated with Prednisone. The treatment groups were given Xingding injection in addition, while the control groups given Aspirin and Persantin. Before and after treatment, 24 hours urine protein quantity, blood plasma albumin, serum creatinine, endogenous creatinine clearance rate and hemorheology indexes were determined. Results After treatment, blood plasma albumin and 24 hours urine protein quantity were both improved significantly in the two groups, while there was no obvious change of serum ereatinine and endogenous creatinine clearance rates. Compared with control group, all hemorheology indexes were improved obviously except platelet gathering rate and erythroeyte sedimentation rate in the treatment groups after treatment. Conclusion The study shows that the improving influences of Xingding injection on hemorheology in patients with PNS were definite, safe and reliable.