丙泊酚复合芬太尼行人工流产术的临床观察

The effect of propofol combining with fentany on painless artificial abortion

目的探讨丙泊酚复合芬太尼进行人工流产术镇痛的临床效果。方法将400例要求无痛人流患者随机分为两组,F组(研究组)常规禁食禁饮后静注芬太尼0.05mg及丙泊酚1.5mg/kg;P组(对照组)常规禁食禁饮后静注丙泊酚1.5mg/kg。术中根据患者肢体扭动反应追加丙泊酚20～30mg/次,并记录两组丙泊酚用量、辅用麻黄碱例数、术后宫缩痛例数及清醒时间、离院时间等。结果研究组丙泊酚用量少于对照组,术后宫缩痛例数少于对照组,差异均有统计学意义(P<0.01),研究组辅用麻黄碱例数少于对照组,差异有统计学意义(P<0.05);两组术中SpO2、清醒时间、离院时间、出现恶心呕吐例数等差异无统计学意义。结论丙泊酚复合芬太尼进行人工流产术镇痛安全有效,临床效果明显优于单独使用丙泊酚。

Objective To compare propefol and combining propofol with fentany for patient with artificial abortion. Methods Four hundreds patients scheduled for painless artificial abortion were raedomized to two groups： 1.5mg/kg of propofol （group P） or 0.05mg of Fentany and 1.5mg/kg of propofol （group F） were administered respectively, Bolus propofol 20-30mg was added when the patient moved danling the operation, lntraoperative heart rate and blood pressure were monitored. Ephedrine added as needed. Operation time, total consumption of propefol, time of wakening, time of stay in the operation room and postoperative uterine contration pain were recorded. Resnlts Total comsumption of propofol was less in group F than in group P （P〈0.01）. Whereas postoperative uterine contration pain in group F was lower than that in group P （P〈0.01）. There were no difference between the two group in SpO2, time of waking, time of stay in the operation room and the rate of PONV. Conclusions Combining fentany and propofol can reduce the consumption of anesthetics comparing to propofol alone for patient of painless artificial abortion.