大肠癌患者红细胞免疫功能研究

Investigation About Immune function Of Red Blood Cell In Patients With Carcinoma of colon and rectum

目的观察大肠癌患者红细胞免疫功能变化,探讨红细胞免疫功能异常在大肠癌发生中的作用。方法采用刘景田改进的微量全血法检测60例大肠癌患者的红细胞免疫功能,并与64例正常人对照分析。结果大肠癌患者红细胞C3b受体花环率(RCR),红细胞C3b受体花环促进率(RFER),自然肿瘤红细胞免疫花环率(NTER)和直向肿瘤红细胞免疫花环率(DTER)明显低于正常人(P<0.01),促肿瘤红细胞免疫花环率(ETER),协同肿瘤红细胞免疫花环率(ATER)低于正常人(P<0.05),而红细胞免疫复合物花环率(RICR)和红细胞C3b受体花环抑制率(RFIR)则明显高于正常人(P<0.01)。结论大肠癌患者的红细胞免疫功能低下是肿瘤形成的一个重要因素,检测其红细胞免疫功能有助于大肠癌的诊断和治疗。

Objective To investigate the changes of RBC immune function in patients with carcinoma of colon and rectum, as well as to discuss the relationship between RBC immune function and carcinoma of colon and rectum. Methods Microdetermination in whole blood for RBC immune function. 60 patients with carcinoma of colon and rectum and 64 normal controls had been determinated. Results When compared between carcinoma of colon and rectum ground and normal control ground, RCR, RICR,RFIR, RFER, NTER,DTER lew els were significantly different （P〈0.01）, FTER,ATER were different （P〈0.05）, Conclusions Immune function of RBC in patients with carcinoma of colon and rectum was lower than normal people. This was an important factor of the tumor formed. The research confirmed that the detection of RBC immune function was useful for diagnosis and treatment of carcinoma of colon and rectum.