1[1]Qiu R G, Chen J, McCormick F, Symons M. A role for Rho in Ras transformation. Proc Natl Acad Sci USA, 1995,92(25): 11781 ～ 11785
2[2]Ridley A J. Rho GTPases and cell migration. J Cell Sci, 2001, 114(15): 2713～ 2722
3[3]Sherr C J, Roberts J M. CDK inhibitors: positive and negative regulators of Gl-phase progression. Genes Dev, 1999, 13(12): 1501 ～1512
4[4]Pervaiz S, Cao J, Chao O S, Chin Y Y, Clement M V. Activation of the Rac GTPase inhibits apoptosis in human tumor cells. Oncogene,2001, 20(43): 6263 ～ 6268
5[5]Cascone I, Giraudo E, Caccavari F, Napione L, Bertotti E, Collard J G, Serini G, Bussolino F. Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network.Adherens junctions and myosin light chain as targets of Racl and RhoA.J Biol Chem, 2003, 278(50): 50702 ～ 50713
6[6]Hirota K, Semenza G L. Racl activity is required for the activation of hypoxia-inducible factor 1. J Biol Chem, 2001, 276(24): 21166 ～21172
7[7]van Nieuw Amerongen G P, Koolwijk P, Versteilen A, van Hinsbergh V W. Involvement of RhoA/Rho kinase signaling in VEGF- induced endothelial cell migration and angiogenesis in vitro. Arterioscler Thromb Vasc Biol, 2003, 23(2) :211 ～ 217
8[8]Soga N, Namba N, McAllister S, Cornelius L, Teitelbaum S L, Dowdy S F, Kawamura J, Hruska K A. Rho family GTPases regulate VEGF-stimulated endothelial cell motility. Exp Cell Res, 2001, 269(1) :73 ～87
9[9]Narayan V I, Lori E K, Faton A, Sandra W L, Erik L, Roland H W,Max G, JohnD G, Ann M L, Aimee Y Y, Gregg L S. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor la.Genes Dev, 1998, 12(1) :149 ～ 162
10[10]Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu M M, Simons J W, Semenza G L. Modulation of hypoxia-inducible factor la eexpression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res, 2000, 60(6): 1541 ～ 1545
