不同剂量腺苷对大鼠自发活动的影响

Effect of Different Dosage Adenosine on the Locomotion Activity in Rats

目的:观察不同剂量腺苷对大鼠自发活动的影响。方法:大鼠分为实验组(分别腹腔注射1、5、10 mg/kg腺苷)和对照组(腹腔注射相同体积的NS);用开场实验分析大鼠自发活动的改变。结果:实验组腹腔注射腺苷后可引起自发活动总路程与中央活动路程减少(P<0.05),休息时间增加(P<0.05);随着腺苷剂量的增加(1、5、10 mg/kg),其自发活动总路程逐渐减少(P<0.05),休息时间逐渐延长(P<0.05),而中央活动路程无明显变化(P>0.05)。结论:腺苷可引起大鼠自发活动的减少,但腺苷是否可致大鼠行为性抑郁还需进一步验证。

Objective： To investigate the effect of different dosage of adenosine on locomotion activity in rats. Methods： The test group was intraperitoneally administrated by different dosage of adenosine（1, 5, 10 mg/kg）, the control group was injected the same volume of NS. The locomotion activity was tested by open field test. Results： In the test group, the total distance and the central distance of rats was decreased by adenosine（P 〈0.05）, and the rest time was increased（P 〈 0.05）. The total distance of rats gradually decreased（P 〈 0.05）and the rest time gradually increased（P 〈 0.05）with the increase of adenosine, but the central distance had no change（ P 〉 0.05）. Conclusion： Adenosine can decrease locomotion activity in rats. But it must be further research if adenosine can cause behavior depression.