不同食管上皮组织中GST-Pi的表达及意义

Expression and significance of GST-Pi in different esophageal tissues

目的探讨食管不同上皮组织中GST-Pi表达以了解其在癌发生发展过程中的作用。方法应用免疫组化SP法观察40例“正常”食管鳞状上皮、10例轻度不典型增生、20例重度不典型增生和40例食管鳞状上皮癌组织中GST-Pi蛋白阳性表达率。结果由正常”食管鳞状上皮-轻度不典型增生-重度不典型增生-食管癌组织中GST-Pi的表达呈逐渐降低的趋势看出,癌组织的表达明显低于正常上皮和轻度增生组,差异均有显著意义(P<0.01)。结论GST-Pi可能与食管癌的发生、发展密切相关。

Objective To explore the expression of glutathione S transferase Pi（GST- Pi） different esophageal tissues and study its significance in the occurence and development of esophageal carcinoma. Methods S P immunohistochemical method was used to detect the expression of GST- Pi protein in 10 cases of normal esophageal epithelium, 10 cases of mild atypical hyperplasia epithelium, 20 cases of severe atypical hyperplasia epithelium and 40 cases of esophageal squamous cell carcinoma. Results There was a declining tendency of the expression of GST Pi protein from normal esophageal epithelium , mild atypical hyperplasia epithelium, severe atypical hyperplasia epithelium to esophageal squamous cell carcino- ma. The expression rate of GST- Pi protein in esophageal squamous cell carcinoma was evidently lower than those in normal esophageal epithelium and mild atypical hyperplasia epithelium, and the differences were significant（ P 〈 0.01 ）. Conclusion The GST- Pi may be closely correlated with the occurrence and development of esophageal carcinoma.