核因子κB抑制蛋白家族的研究进展

Advances in IκB protein family research

IκB is an inhibitor of nuclear factor-kappa B(NF-κB) and presents in the majority of cells.Eightstructurally related members of the mammalian IκB family have been described: IκBα,IκBβ,IκBε,Bcl-3,IκBγ,IκBδ,p100 and p105.The ankyrin repeat domain of IκB can interact with NF-κB,and sequester NF-κB in the cytoplasm as in-active complexes.Most recently,IκBαhas been found to inhibit p53 tumor suppressor protein by binding p53 to form a cyto-plasmic p53.IκBαcomplex and studies have shown that p100 profoundly sensitizes cells to death-receptor-mediated ap-optosis.The current review is to describe the members of IκB family,their related signaling pathways,and their applicationin tumor therapy.

IκB is an inhibitor of nuclear factor - kappa B （ NF -κB） and presents in the majority of cells. Eight structurally related members of the mammalian IκB family have been described ： IκBet, IκBα, IκBβ, Bcl - 3, IκBγ, IκBδ, p100 and p105. The ankyrin repeat domain of IκB can interact with NF -κB, and sequester NF -κB in the cytoplasm as inactive complexes. Most recently, IκBα has been found to inhibit p53 tumor suppressor protein by binding p53 to form a cytoplasmic p53 · IκBα complex and studies have shown that p1000 profoundly sensitizes cells to death - receptor - mediated apoptosis. The current review is to describe the members of IκB family, their related signaling pathways, and their application in tumor therapy.