摘要
目的:探讨端粒酶的调节基因TRAP在皮肤基底细胞癌中的表达情况。方法:用免疫组化S-P法检测TRAP在38例皮肤基底细胞癌、15例正常皮肤中的表达。结果:TRAP在皮肤基底细胞癌的表达高于正常皮肤(P<0.01);在未分化型与分化型基底细胞癌表达的差异无统计学意义。结论:TRAP的异常高表达可能与皮肤基底细胞癌的发病有关。TRAP的表达与基底细胞癌的病理分型无关。
Objectives： To investigate the expression of telomerase regulation gene TRAP in the basal cell carcinoma. Methods：The expression of TRAP was detected with S- P immunohistochemical method in 38 cases of basal cell carcinoma and 15 case of normal skin. Results： The expression of TRAP was higher in the basal cell carcinoma than that in the normal skin （P （0.01）, and the difference in the expression of TRAP between undifferentiation basal cell carcinoma and differentiation basal cell carcinoma was not significant （P 〉0.05）. Conclusions： The abnormal expression of TRAP may contribute to the pathogenesis of basal cell carcinoma, The expression of TRAP may not related to pathological type in basal cell carcinoma.
出处
《内蒙古医学杂志》
2006年第11期989-991,共3页
Inner Mongolia Medical Journal
