胺碘酮治疗恶性室性心律失常的疗效评价

Effect of Amiodaron on Malignant Ventricular Arrhythmia

目的：评价胺碘酮治疗恶性室性心律失常的疗效。方法：对我院1998～2005年收住CCU的36例恶性室性心律失常患者随机分成两组。治疗组20例，采用电复律及胺碘酮，转复成功后用胺碘酮维持窦律。对照组16例，应用利多卡因及电复律转复并维持窦律。无效改用胺碘酮。结果：治疗组转复成功率75％（6／8），维持窦律成功率81．81％（9／11），总有效率75％（15／20），均高于对照组55．56％（5／9）、57．14％（4／7）、56．25％（9／16），且利多卡因转复失败部分病例用胺碘酮仍有效。结论：胺碘酮是治疗恶性室性心律失常的有效药物之一。应用其他抗心律失常药无效的病例应用胺碘酮仍有效。

Objective： To evaluate the effect of amiodaron on malignant ventricular arrhythmia. Methods： 36 cases of malignant ventricular arrhythmia hospitalized from 1998 to 2005 were divided into two groups： treatment group（n= 20） and control group （n= 16）. In treatment group, electrical conversion and amiodaron were used for cardioversion and amiodaron for maintenance of sinum rhythm, In contral group, lidocaine and electrical conversion were used for cardioversion and maintenace of sinum rhythm, and amiodaron was used in ineffective ones. Results： In treatment group, The Success rate of cardioversion was 75%, that of maintenace of sinum rhythm was 81.81%, and total effective rate was 75%, which was higher than that of Controls （55.56%, 57.14 %, 56.25 %, respectively）. Amiodaron was still effective in those who was ineffective with lidocaire. Conelusion： Amioelaron is effective in treating malignant ventricular arrhythmia. Amiodaron also can be used in Patients who was failure in treating arrhythmia with other antiarrhythic drugs.