期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

小鼠骨髓间充质干细胞在体外对淋巴细胞增殖和凋亡的影响 被引量：1

原文传递
导出
摘要 骨髓间充质干细胞（MSC）是骨髓基质祖细胞，具有多向分化潜能，可应用于各种组织的修复和重建。MSC同时还具有调节免疫系统的作用。在体内及动物实验中，MSC可以减少移植物抗宿主病的发生率并减轻其严重程度。能够延长皮肤移植物的存活时间。国内也有资料显示MSC能够抑制脐血淋巴细胞的转化。但MSC对淋巴细胞的免疫抑制作用机制尚不清楚。我们对此进行了探索。
作者 曾婷婷 贾永前 王兰兰 潘晓夫 杨寒朔 魏于全
机构地区 四川大学华西医院实验医学科 四川大学华西医院血液科 生物治疗国家重点实验室
出处 《中华血液学杂志》 CAS CSCD 北大核心 2006年第12期840-841,共2页 Chinese Journal of Hematology
基金 国家863计划资助项目(2002AA205061) 纽约中华医学基金(CMB)资助项目
关键词 骨髓间充质干细胞 淋巴细胞增殖 骨髓基质祖细胞 移植物抗宿主病 凋亡 体外 小鼠 多向分化潜能
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献9

  • 1Rasmusson I,Ringdén O,Sundberg B,et al.Mesenchymal stem cells inhibit the formation of cytotoxie T lymphocytes (CTL),but not activated CTL or natural killer (NK) cells.Transplantation,2003,76:1208-1213.
  • 2Glennie S,Soeiro I,Dyson PJ,et al.Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells.Blood,2005,105:2821-2827.
  • 3Aggarwal S,Pittcnger MF.Human mesenchymal stem cells maulate allogeneie immune cell responses.Blood,2005,105:1815-1822.
  • 4Le Blanc K,Rasmusson I,Sundberg B,et al.Treatment of severe acute graft-versus host disease with third party haploidentical mesenchymal stem cells.Lancet,2004,363:1439-1441.
  • 5Bartholomew A,Sturgeon C,Siatskas M,et al.Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.Exp Hematol,2002,30:42-48.
  • 6何津,张毅,江小霞,刘刚,刘元林,李荷莲,毛宁.人骨髓间充质干细胞对脐血T淋巴细胞转化的影响[J].中国实验血液学杂志,2003,11(1):11-14. 被引量：21
  • 7Nieola MD,Carlo-Stella C,Magni M,et al.Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenie.Blood,2002,99:3838-3843.
  • 8Krampera M,Glennie S,Dyson J,et al.Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide.Blood,2003,101:3722-3729.
  • 9Le Blanc K,Rasmusson I,Gotherstrom C,et al.Mesenehymal stem cells inhibit the expression of CD25 (Interleukin-2 Reeeptor) and CD38 on phytohaemagglutinin-aetivated lymphoeytes.Seand J Immunol,2004,60:307-315.

二级参考文献8

  • 1[1]Devine SM, Hoffman R. Role of mesenchymal stem cells in hematopoietic stem cell transplantation. Cur Opin Hematol, 2000;7: 358 - 363
  • 2[2]Friedenstein AJ, Chailakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet, 1987; 20:263- 272
  • 3[3]Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science, 1999; 284(5411): 143 - 147
  • 4[4]Deans RJ, Moseley AB. Mesenchymal stem cells: Biology and potential clinical uses. Exp Hematol, 2000; 28: 875 - 884
  • 5[5]Klyushnenkova E, Mosca J, McIntosh K. Human mesenchymal stem cells suppress allergenic T cell responses in vitro: implications for allergenic transplantation. Blood, 1998; 92:642a
  • 6[6]McIntosh K, Klyushnenkova E, Shustova V, et al. Suppression of alloreactive T cell response by human mesenchymal stem cells involves CD8+ cells. Blood, 1999; 94:133a
  • 7[7]Bartholomew A, Sturgeon C, Nelson M, et al. Allergenic mesenchymal stem cells have significant immunosuppressive activity.Exp Hematol, 1999; 27:123a
  • 8[8]Le Blanc K, Tammik C, Sundberg B, et al. Inhibition or enhancement of mixed lymphocyte cultures by allogeneic and autologous mesenchymal stem cells is dependent on cell dose. The 43rd annual meeting of american society of hematology in 2001

共引文献20

同被引文献10

  • 1Nauta A J, Fibbe WE Immunomodulatory properties of mesenchymal stromal cells. Blood, 2007 ; 110 : 3499 - 3506.
  • 2Sharpe AH, Wherry EJ, Ahmed R, et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol, 2007 ; 8 : 239 - 245.
  • 3Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood, 2005; 105: 1815 - 1822.
  • 4Di-Nicola M, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood, 2002; 99: 3838 - 3843.
  • 5Bartholomew A, Sturgeon C, Siatskas M, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol, 2002; 30:42 -48.
  • 6Yanez R, Lamana ML, Garcia-Castro J, et al. Adipose tissuederived mesenchymal stem ceils have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease. Stem Cells, 2006; 24:2582-2591.
  • 7Le-Blanc K, Rasmusson I, Sundberg B, et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet, 2004; 363(9419) : 1439 -1441.
  • 8Stagg J, Galipeau J. Immune plasticity of bone marrow-derived mesenchymal stromal cells. Handb Exp Pharmacol, 2007 : 45 - 66.
  • 9Tse WT, Pendleton JD, Beyer WM, et al. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation, 2003 ; 75 : 389 - 397.
  • 10何津,张毅,江小霞,刘刚,刘元林,李荷莲,毛宁.人骨髓间充质干细胞对脐血T淋巴细胞转化的影响[J].中国实验血液学杂志,2003,11(1):11-14. 被引量：21

引证文献1

中华血液学杂志
2006年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部