胰腺外分泌不足病人的胰酶替代治疗

The replacement therapy of pancreatic enzyme

胰酶主要用于胰腺外分泌功能不足的病人,如囊性纤维化、胰切除术后、全胃切除术后以及慢性胰腺炎。该文作者就胰酶的替代治疗作如下综述,主要包括胰腺外分泌功能的评估,胰腺外分泌不足的发病机制,胰酶制剂的多种形式及其疗效,胰酶使用的剂量,肠内营养与胰酶替代治疗的关系以及使用胰酶的不良反应等。

Pancreatic enzyme replacement therapy is given to manage pancreatic exocrine insufficiency （PEI） in cystic fibrosis （CF） and following pancreateetomy, total gastrectomy or chronic pancreatitis. The article reviews on aspects of pancreatic enzyme replacement therapy containing the assement of pancreatic exocrine function, the pathogenesis of exocrine pancreatic insufficiency, pancreatic enzyme preparations and their efficiency, dosing of pancreatic enzymes, enteral nutrition and pancreatic enzyme replacement, the modulation of pancreatic exocrine and adverse reactions to pancreatic enzyme.