广东省371例早发性脑卒中患者发病危险因素的研究

A Case-Control Study on the Risk Factors of Premature Stroke

目的探索广东省早发性脑卒中患者发病的危险因素。方法从广东省7个城市18所医院住院病人中收集早发性(≤45岁)脑卒中病人371名(Ⅰ组);选取相同数量的老年脑卒中病人(>60岁)作为老年对照组(Ⅱ组);并按1∶1配对方法选取青年对照组人群(Ⅲ组)进行病例对照研究。结果单因素分析结果表明,早发性脑卒中发病的危险因素是BMI>24、高血压史、病前血压波动、高脂血症史、高血压家族史、吸烟、饮酒等因素,而高血压家族史和病前血压波动史进入多因素条件Logistic回归模型(OR值分别为3.704和13.511)。结论早发性脑卒中的防治需采取综合干预措施,重点是控制血压及改变不良的生活方式和饮食习惯,保持良好的精神心理状态。

Objective To explore the risk factors for premature stroke, in order to prevent and control the occurrence of premature stroke. Methods In 2004, the participants from 18 hospitals in 7 citys of Guangdong province were divided into three groups, ease group （group Ⅰ ） contained 371 premature stroke patients, the elderly stroke group （group Ⅱ ） and 1 ： 1 matched premature healthy group （group Ⅲ ）. A case - control study was used. Results The family history of hypertension and the fluctuation of blood pressure entered the multiple conditional Logistic regression model, and their OR were 3.704 （95% CI 1.511 - 9.078） and 13.511 （95% CI 3.002 - 60.830） respectively. Conclusion It is necessary to implement a comprehensive prevention program, such as keeping blood pressure tranquilization and lifestyle and dietary habit modification, keeping good psychosis preservation.