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Barrett食管化学预防机制研究进展 被引量:1

Chemoprevention strategies study of Barrett esophagus
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摘要 Barrett食管(BE)是胃食管反流病(GERD)的一种并发症,与食管腺癌密切相关。随着GERD发病率的增高,BE、食管腺癌的发病率也逐年增高。胃食管反流、酸暴露是重要的的发病因素,由于环氧合酶-2(COX-2)在BE、食管腺癌的早期高表达使得非甾体类消炎药(NSAID)及选择性COX-2抑制剂在BE的化学预防方面显得尤其重要。 Barrett esophagus(BE)is a complication of chronic gastroesophageal reflux disease(GERD)associated with an increased risk of esophageal adenocarcinoma. The incidence of GERD.BE and esophageal adenocarcinoma have increased rapidly in past years. Gastroesophageal reflux and acid exposure are important factors. The finding that cyclooxygenase-2(COX-2)early and overexpressed in BE and esophageal adenocarcinoma implies that nonsteroidal anti-inflammatory drugs(NSAID) and selective cyclooxygenase-2 inhibitor would have a role in the chemoprevention of BE.
出处 《国际消化病杂志》 CAS 2006年第6期394-396,共3页 International Journal of Digestive Diseases
关键词 BARRETT食管 胃食管反流病 酸暴露 环氧合酶-2 化学预防 Barrett esophagus Gastroesophageal reflux disease Acid exposure Cyclooxygenase-2 Chemoprevention
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