活动性炎症性肠病与血小板参数的相关性及其临床意义

Association of activity of inflammatory bowel disease with platelet parameters and its clinical implications

目的研究炎症性肠病(IBD)患者血液中血小板计数和平均血小板体积是否可以作为评价IBD活动性的参考指标。方法选取IBD病例160例,其中溃疡性结肠炎(UC)85例,克隆病(CD)75例;非IBD病例121例。摘录病例中的血小板计数和平均血小板体积。结果UC和CD病例中的血小板计数均比非IBD病例高,而平均血小板体积均比非IBD病例低,差异有统计学意义。血小板计数和平均血小板体积均与UC的炎症程度分级有相关关系,与CD的简易CD活性指数评分也有相关关系。结论血小板计数和平均血小板体积可作为评价IBD活动性的参考指标。

Objective To study role of platelet count and mean platelet volume in evaluation of inflammatory bowel disease（IBD） activity. Methods A retrospective analysis was performed in 160 patients with IBD in past 6 years, including 85 patients with ulcerative colitis （UC） and 75 patients with Crohn disease（CD）, and 121 patients without IBD, then extracted the platelet count, mean platelet volume. Results Platelet count was increased in patients with UC and CD compared to patients without IBD. On the other hand, mean platelet volume was significantly decreased in patients with UC and CD compared to patients without IBD. Mean platelet volume and platelet count were correlated with classification of inflammation level truelove＇s index for UC and scores of simple CD activity index. Conclusions It is proposed that the platelet count and mean platelet volume would provide useful markers of activity of IBD.