期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

展示白色念珠菌热休克蛋白表位的杂合噬菌体诱导小鼠产生的体液免疫应答反应研究 被引量：1

The humoral response induced by hybrid phage displaying Candida albicans hspqo epitope in mice
下载PDF
导出
摘要 白色念珠菌HSP90 LKVIRK是一段保守的B细胞线性表位.利用展示有LKVIRK表位的杂合噬菌体作为抗原,免疫C57BL/6J小鼠,然后在小鼠的系统性念珠菌感染模型中评价其免疫保护作用.结果证明该杂合噬菌体能够诱导C57BL/6J小鼠产生高滴度的抗HSP90抗体,而且对系统性念珠菌感染的小鼠具有免疫保护作用.说明展示有白色念珠菌LKVIRK表位的杂合噬菌体有可能成为一种候选的真菌疫苗. The peptide LKVIRK on heat shock protein （Hsp） 90 of Candida albicans is a conserve and liner B-cell epitope. The efficacy of hybrid phage particles displaying LKVIRK in inducing immune protection response were studies in C57BL/6J murine model of systemic C. albicans infection. Immunized animals produce a high level of HSP90-specific protective antibody response against invasive candidiasis. These results indicate that the hybrid phage may serve as a potential anti-C, albicans vaccine.
作者 杨琼 温得中 苏全平 王丽
机构地区 东北师范大学遗传与细胞研究所 吉林大学基础医学院
出处 《东北师大学报（自然科学版）》 CAS CSCD 北大核心 2006年第4期106-109,共4页 Journal of Northeast Normal University(Natural Science Edition)
基金 国家自科学基金资助项目(30471602) 东北师范大学自然科学青年基金资助项目(20050405) 长春市社会发展科学计划项目(05GG76)
关键词 系统性白色念珠菌感染 HSP90 表位 抗体 system Candia albicans infection HSP90 epitope antibody
分类号 R392.7 [医药卫生—免疫学]
  • 相关文献

参考文献8

  • 1MATTHEWS R C,RIGG G,HODGETTS S,et al.Preclinical assessment of the efficacy of mycograb,a human recombinant antibody against fungal HSP90[J].Antimicrob Agents Chemother,2003,47(7):2 208-2 216.
  • 2王丽.多肽在丝状噬菌体外壳蛋白上的展示[J].东北师大学报（自然科学版）,1998(1):46-48. 被引量：1
  • 3PORTEFAIX J M,FANUTTI C,GRANIER C,et al.Detection of anti-p53 antibodies by ELISA using p53 synthetic or phage-displayed peptides[J].J Immunol Methods,2002,259(1-2):65-75.
  • 4杨琼,宋祥福,王桂云.系统性白色念珠菌感染小鼠动物模型的研究[J].东北师大学报（自然科学版）,2005,37(2):86-89. 被引量：14
  • 5WU Y ZH,WAN Y,BIAN J,et al.Phage display particles expressing tumor-specific antigens induce preventive and therapeutic anti-tumor immunity in murine P815 model[J].Int J Cancer,2002,98(5):748-753.
  • 6GREENWOOD J,WILLIS A E,PERHAM R N.Multiple display of foreign peptides on a filamentous bacteriophage.Peptides from plasmodium falciparum circumsporozoite protein as antigens[J].J Mol Biol,1991,220(4):821-827.
  • 7BASTIEN N,TRUDEL M,SIMARD C.Protective immune responses induced by the immunization of mice with a recombinant phage displaying an epitope of the human respiratory syncytial virus[J].Virology 1997,234 (1):118-122.
  • 8GAUBIN M,FANUTTI C,MISHAL Z,et al.Processing of filamentous phage virions in antigen-presenting cells targets both HLA class I and class II peptide loading compartments[J].DNA Cell Biol,2003,22:11-18.

二级参考文献9

  • 1王林发,郁萌.利用丝状噬菌体展示技术进行抗原决定族图谱及其基因工程的研究[J].生物工程学报,1996,12(3):235-246. 被引量：4
  • 2Maertens J, Vrebos M, Boogaerts M. Assessing risk factors for systemic fungal infections[J]. Eur J Cancer Care,2001,10(1)56-62.
  • 3Bromuro C,Torosantucci A, Chiani P,et al. Interplay between protective and inhibitory antibodies dictates the outcome of experimentally disseminated candidiasis in recipients of a Candida albicans Vaccine [J]. Infection and Immunity, 2002,70(10):5462-5470.
  • 4Bromuro C, La Valle R, Sandini S, et al. A 70 - Kilodalton recombinant heat shock protein of Candida albicans is highly immunogenic and enhances systemic murine candidiasis[J]. Infect Immun, 1998, 66 (5): 2154-2162.
  • 5Bystricky S, Paulovicova E, Machova E. Candida albicans mannan-protein conjugate as vaccine candidate[J]. Immunol Lett,2003,85(3) :251 - 255.
  • 6Matthews R, Hodgetts S, Burnie J. Preliminary assessment of a human recombinant antibody fragment to hsp90 in murine invasive candidiasis[J]. J Infect Dis, 1995 ,171(6):1668 - 1671.
  • 7Shadkchan Y, Segal E. Antifungal activity of amphotericin B- lipid admixtures in experimental systemic candidosis in naive mice[J]. J Antimicrob Chemother, 1999,44(6) :787 - 790.
  • 8Cardenas- Freytag L, Cheng E, Mayeux P,et al. Effectiveness of a vaccine composed of heat - killed Candida albicans and a novel mucosal adjuvant, LT(RI92G), against systemic candidiasis[J]. Infect Immun, 1999,67(2):826-833.
  • 9王桂云,朱筱娟,王丽.噬菌体展示外源多肽的免疫原性研究[J].东北师大学报（自然科学版）,2001,33(3):101-104. 被引量：11

共引文献13

同被引文献6

  • 1杨琼,宋祥福,王桂云.系统性白色念珠菌感染小鼠动物模型的研究[J].东北师大学报（自然科学版）,2005,37(2):86-89. 被引量：14
  • 2杨琼,苏全平,温得中,王丽.系统性白色念珠菌感染的免疫应答反应及疫苗研究进展[J].生理科学进展,2006,37(3):259-262. 被引量：8
  • 3YANG QIONG,WANG LI,LU DA-NING,et al.Prophylactic vaccination with phage-displayed epitope of C.albicans elicits protective immune responses against systemic candidiasis in C57BL/6 mice[J].Vaccine,2005,23(31):4088-4097.
  • 4MONOD M,HUBE B,HESS D,et al.Differential regulation of SAP8 and SAP9,which encode two new members of the secreted aspartic proteinase family in Candida albicans.[J].Microbiology,1998,144:2731-2737.
  • 5MORRISON C J,HURST S F,REISS E.Competitive binding inhibition enzyme-linked immunosorbent assay that uses the secreted aspartyl proteinase of Candida albicans as an antigenic marker for diagnosis of disseminated candidiasis.[J].Clin Diagn Lab Immunol,2003,10(5):835-848.
  • 6王丽,朱筱娟.白色念珠菌热休克蛋白90[J].科学通报,1999,44(23):2476-2480. 被引量：1

引证文献1

东北师大学报（自然科学版）
2006年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部