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CaMKⅡ与心肌肥厚 被引量：2

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作者 柯俊 张存泰 马业新
机构地区 华中科技大学同济医学院附属同济医院心内科
出处 《中国心血管病研究》 CAS 2006年第12期936-938,共3页 Chinese Journal of Cardiovascular Research
基金 国家自然科学基金资助项目(30470714)
关键词 CaMKⅡ 心肌肥厚 CA^2+/CAM 钙调蛋白激酶Ⅱ 扩张性心肌病 信号转导通路 室性心律失常 信号转导途径
分类号 R392.12 [医药卫生—免疫学]
  • 相关文献

参考文献16

  • 1[1]Zhang T,Brown JH.Role of Ca2+/calmodulin-dependent protein kinase Ⅱ in cardiac hypertrophy and heart failure.Cardiovasc Res,2004,63:476-486.
  • 2[2]Kolodziej SJ,Hudmon A,Waxham MN,et al.Three-dimensional reconstructions of calcium/calmodulin-dependent CaM kinase Ⅱcand truncated CaM kinase Ⅱα reveal a unique organization for its structural core and functional domains.J Biol Chem,2000,275:14354-14359.
  • 3[3]Dupont G,Houart G,De Koninck P,et al.Sensitivity of CaM kinase Ⅱ to the frequency of Ca2+ oscillations:a simple model.Cell Calcium,2003,34:485-497.
  • 4[4]Gaertner TR,Kolodziej SJ,Wang D,et al.Comparative analyses of the three-dimensional structures and enzymatic properties of alpha,beta,gamma and delta isoforms of Ca2+calmodulin dependent protein kinase Ⅱ.J Biol Chem,2004,279:12484-12494.
  • 5[5]Hcch B,Wobus AM,Krause EG,et al.Delta-Ca2+/calmodulindependent protein kinase Ⅱ expression pattern in adult mouse heart and cardiogenic different-tiation of embryonic stem cells.J Cell Biochem,2000,79:293-300.
  • 6[6]Bradshaw JM,Hudmon A,Schulman H,et al.Chemical quenched flow kinetic studies indicate an intraholoenzyme autophosphorylation mechanism for Ca2+/Calmodulin dependent Protein Kinase Ⅱ.J Biol Chem,2002,277:20991-20998.
  • 7[7]Ramirez MT,Zhao XL,Schulman H,et al.The Nuclear deltaB Isoform of Ca2+/calmodulin-dependent protein kinase Ⅱ regulates atrial natriuretic factor gene expression in ventricular myocytes.J Biol Chem,1997,272:31203-31208.
  • 8[8]Kashiwase K,Higuchi Y,Hirotani S,et al.CaMKⅡ activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy.Biochem Biophys Res Commun,2005,327:136-142.
  • 9[9]Zhang T,Johnson EN,Gu Y,et al.The cardiac-specific nuclearB Isoform of Ca2/calmodulin dependent protein kinase Ⅱ induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity.J Biol Chem,2002,277:1261-1267.
  • 10[10]Dzhura Ⅰ,Wu Y,Colbran RJ,et al.Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels.Nat Cell Biol,2000,2:173-177.

同被引文献26

  • 1邹操,刘志华,赵彩明,蒋彬,宋建平,杨向军,蒋廷波,杨俊华,蒋文平.超容量负荷联合压力负荷制备家兔心衰模型的可行性探讨[J].实验动物与比较医学,2005,25(4):211-214. 被引量：31
  • 2Maier LS,Bers DM. Role of Ca^2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart.Cardiovasc Res, 2007,73 : 631-640.
  • 3Kashiwase K, Higuchi Y, Hirotani S, et al. CaMK Ⅱ activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy. Biochem Biophys Res Commun,2005,327:136-142.
  • 4Ramirez MT,Zhao XL,Sehulman H,et al. The nuclear delta B isoform of Ca^2+/calmodulin-dependent protein kinase Ⅱ regulates atrial natriuretic factor gene expression in ventricular myocytes. J Biol Chem, 1997,272 : 31203-31208.
  • 5Zhang T, Maier LS, Dalton ND, et al. The dehaC isoform of CaMK Ⅱ is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res, 2003,92 : 912-919.
  • 6Kawai T,Nomura F,Hoshino K,et al. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Oncogene, 1999,18 : 3471-3480.
  • 7Wu Y, Kimbrough JT, Colbran RJ, et al. Calmodulin kinase is functionally targeted to the action potential plateau for regulation of L-type Ca^2+ current in rabbit cardiomyocytes. J Physiol, 2004,554: 145-155.
  • 8Hund TJ, Rudy Y. A role for calcium/calmodulin-dependent protein kinase Ⅱ in cardiac disease and arrhythmia. Handb Exp Pharmacol, 2006,171 : 201-220.
  • 9Care A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy. Nature Medicine, 2007,13 : 5.
  • 10Ivey KN, Muth A, Arnold J, et al. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell, 2008,2 : 219-229.

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二级引证文献3

中国心血管病研究
2006年 第12期

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