广泛性焦虑遗传效应和遗传方式研究

A study of genetic effects and genetic mode of generalized anxiety disorder

目的:探讨广泛性焦虑的遗传效应和遗传方式。方法:对80例符合中国精神障碍分类与诊断标准第3版广泛性焦虑诊断标准的患者,应用家族史法进行研究,采用分离分析法和多基因阈值理论进行遗传模式的探讨。结果:广泛性焦虑患者一级亲属发病危险性显著较对照组高(P<0.01);广泛性焦虑校正分离率为0.225,与常染色体隐性遗传的分离率0.25相比较,差异无显著性(P>0.05);广泛性焦虑加权平均遗传率和标准误为(61.70±5.10)%;一级亲属的预期发病率为8.9%,实际发病率为7.5%,二者差异无显著性(P>0.05)。结论:广泛性焦虑具有遗传效应,其遗传方式符合常染色体隐性遗传或多基因遗传。

Objective：To explore the genetic effects and the genetic mode of generalized anxiety disorder. Method：All 80 patients who met Chinese classification of mental disorder, third edition criteria for generalized anxiety disorder were recruited. Family history method were used, and the segregation analysis and polygenic threshold theory were applied to analyze the genetic mode. Results：The prevalence rate of generalized anxiety disorder in the first degree relatives of the proband was higher significantly than that in the control group（ P 〈 0.01 ）. The segregative rate in generalized anxiety disorder was 0. 225, which was not significantly different （ P 〉 0.05 ） from the segregation rate 0.25 in aotosome recessive inheritance. The weighted mean of heritability and standard error was （61.70 ± 5.10） %. No significant difference was found between the expected incidence of generalized anxiety disorder （8.9%） and the actual incidence 7.5% in the first-degree relatives. Conclusion：The findings suggest that generalized anxiety disorder has evident genetic effects, and the mode of genetic of generalized anxiety disorder may conform to autosomal recessive inheritance or polygenic inheritance.