五味清热饮预防发热药效学研究

Study on Pharmacodynamics in Preventing Fever by Taking Wuweiqingreyin

目的:研究五味清热饮在大鼠的预防发热作用。方法:大鼠口服正柴胡饮及高、中、低剂量五味清热饮30分钟后,皮下注射2,4-二硝基苯酚30 mg/kg致大鼠发热,观察0.5、1.0、1.5、2.0、2.5、3.0、4.0及5.0 h大鼠体温变化。结果:与对照组比较,五味清热饮高、中、低剂量组于给药后0.5、1.0、1.5、2.0、2.5及3.0 h对大鼠体温均具有非常显著的降低作用(P<0.01)。结论:五味清热饮对2,4-二硝基苯酚致大鼠发热有明显的预防作用。

Objective ： To study the effect of Wuweqingreyin on preventing fever in rats. Methods ：Thirty minutes after the oral administration of high,medium or low doses of Wuweiqingreyin respectively, 2,4-dinitrophenol（ 30 mg/kg） was injected to induce fever in rats. Then body temperature was recorded 0.5,1.0,1.5,2.0,2.5,3.0,4.0 and 5.0 h after the injection. Results ： Compared with that of the saline control group,there was an obvious drop in the body temperature in Wuweiqinreyin groups. Conclusion：Wuweiqingreyin has an obvious effect in preventing the rat fever induced by 2,4- dinitrophenol.