肾移植术后痛风的治疗

Treatment of gout in kidney transplantation recipients

目的 探讨肾移植术后痛风的发生机制及防止策略。方法 分析512例肾移植患者的临床资料。结果 其中发生痛风性关节炎有35例，随访1—5年，4例症状控制不理想，余血尿酸控制在正常范围。结论 高尿酸血症及痛风是肾移植术后较常见的并发症，主要与患者肾功能减退、长期应用环孢素A（CaA）和利尿剂有关。患者的用药及饮食指导可降低痛风的发生。

Objective To investigate the mechanism and therapeutic strategy of gout after renal transplantation. Methods The clinical data of 35 patients with gout among 512 renal transplantation recipients were analyzed. Results 35 patients with gout were followed up for 1 to 5 years. Blood uric acid level and symptom were controlled effectively except 4 patients. Condclsion Gout is a common complication of renal transplantation, its mechanism are mainly attributable to CsA and diuretic use especially in renal dysfunctional patients. A guide to medication and foods can be of great effect on prevention of gout.