2~7岁小于胎龄儿血清瘦素水平与生长关系的研究

Study on the correlation between the levels of serum leptin and the growth of children aged 2～7 years old with small for gestational age.

【目的】检测小于胎龄儿（small for gestational age，SGA）2-7岁阶段血清瘦素，探讨其与SGA生长的关系。【方法】采用放射免疫法测定60例2～7岁SGA和40例2～7岁适于胎龄儿（appropriate for gestational age，AGA）血清瘦素水平。【结果】①SGA组儿童的血清瘦素水平明娃低于AGA组（P〈0．001）；②血清瘦紊水平与体重、身长、年龄、体质指数呈正相关；③无论是SGA组，还是AGA组，女童血清瘦素水平显著高于同组的男童（P〈0．05）。【结论】瘦素参与2～7岁儿童的生长过程，并可作为评价此阶段儿童营养状况的指标。

[Objective] To study the levels of serum leptin and their roles on the growth of children aged 2-7 years old with small for gestational age（SGA）. [Methods] A group of 60 SGA and 40 appropriate for gestational age（AGA） children aged 2 to 7 were assigned to an experimental group and a control group. The serum level of leptin was measured by radioimmunoassay（RIA）. [Results] （1）The level of serum leptin in SGA group was much lower than that in AGA group and statistic significance difference was showed（P〈0. 001）. （2）There was a positive correlation between serum leptin level and body weight, length, and age. （3）In both SGA group and AGA group, the level of serum leptin in female was significantly higher than that in male（P〈0. 05）, [Conclusions] This shows that leptin is an important factor in the growth of children of 2-7 years old group. The level of serum leptin may be a marker of nutritional status in children of this age group.