莫西沙星在间质性肺疾病治疗中的预防性应用

Prophylactic Application of Moxifloxacin in the Treatment of Interstitial Lung Diseases

目的研究莫西沙星在间质性肺疾病(interstitial lung diseaSe,ILD)治疗中用以预防性应用的可行性和有效性。方法选择同济大学附属肺科医院呼吸科2005年1月至2005年12月140例ILD激素治疗患者,随机单盲均分为莫西沙星组和其他抗生素组(对照组),比较两种方法对ILD患者激素治疗过程中预防或减轻呼吸道继发感染的作用以及效价比。结果莫西沙星组患者痰细菌清除率及临床有效率高于对照组,胃肠道功能紊乱、肝损、皮疹的发生率低于对照组,未发生肾损及其他不良反应。结论莫西沙星由于抗菌谱广、抗菌活性强、不良反应小,在ILD患者激素使用过程中作为预防性治疗具有其独特的优势。

Objective To study the feasibility and effect of Moxifloxacin in the treatment of interstitial lung disease （ILD） for prophylactic application. Methods 140 ILD patients treated with corticosteroids in Shanghai Pulmonary Hospital from January to December in 2005 were enrolled into the study and they were divided into two groups randomly into, two groups randomly,including the group of Moxifloxacin（ n = 70） and the group of other antibiotics （ n = 70）, as compare group. The effect of the two methods in ILD patients with corticosteroids therapy for prevention or alleviation of secondly infection in respiratory tract to gether with the ratio of effect iveness to price were compared. Results After treatment with Moxifloxacin, the percentage of sputum bacteria clearance and clinical effect rate of the patients were higher than the control group. The occurrence rate of the gastrointestinal tract adverse effect, damage of the liver and rash were lower than the control group. And the renal damage and other adverse effects weren＇ t found. The average days of staying in hospital and the times of in-hospital were also lower than the control group. Conclusion Comparing with other antibiotics, Moxifloxacin has a broader antibiotic spectrum, more efficient antibiotic effect and less adverse effects. So, Moxifloxacin owns special advantanges of prophylaxis antibiotic treatment in ILD patients with steroid therapy.