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低分子右旋糖酐对肾病综合征的利尿效果分析 被引量:2

Effect of combination with flurosemide on nephritic syndrome
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摘要 目的观察低分子右旋糖酐对原发性肾病综合征的利尿作用。方法60例原发性肾病综合征的患者,分别采用:(1)速尿(1 mg/kg)+安慰剂;(2)速尿(1 mg/kg)+20%白蛋白50 ml;(3)速尿(1 mg/kg)+ 250 ml低分子右旋糖酐进行治疗,并测其24 h尿量、尿肌酐、尿钠、心钠素(ANP)、血尿素氮、血肌酐及血压。结果单用速尿能增加尿量及尿钠(P<0.05),但不增加血ANP。低分子右旋糖酐联用速尿或白蛋白联用速尿均能使尿量及尿钠、血ANP明显增加(P<0.05),低分子右旋糖酐联用速尿不引起肾功能的损害。结论低分子右旋糖酐能替代白蛋白起同等利钠利尿效果,且无白蛋白的副作用。 Objective To observe the diuretic effect of Dextrans on primary nephritic syndrome. Methods In adoutble-blind placebo-controlled study,60 cases of primary nephritic syndrome patients were randomly devided into three groups and received by intravenous administration for 60 minutes for three days:(1 )FU(1 mg/kg) combination with as ham infusion ; (2) FU ( 1 mg/kg) combination with 50ml of 20 % solution of albumin; ( 3 ) FU ( 1 mg/ kg) combination with 250ml dextran. Urinary volume, sodium and plasma atrial nartiuretic peptide concentration were assessed. Results The results showed that administration of FU alone could increase mean cumulative urinary sodium and volume excretion( P 〈 0.05) but didn' t increase plasma ANP. The administration of FU and albumin or FU and dextran could result to even more marked increase of urinary sodium,volume excretion and plasma ANP(P 〈 0.05). The administration of Dextran and FU didn't cause renal function damage. Conclusion Conclusion Dextran 40 can substitute albumin because of the same diuretic effect and no side effect of albumin.
作者 陈玮玲
出处 《中国基层医药》 CAS 2006年第11期1788-1789,共2页 Chinese Journal of Primary Medicine and Pharmacy
关键词 右旋糖酐类 肾病综合征 Dextrans Nephrotic syndrome
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