西安地区学龄前儿童乙肝表面抗体水平调查

Study and investigate of HBsAb of preschool children in Xi'an

目的探讨学龄前儿童注射乙型肝炎疫苗后,乙型肝炎表面抗体(HBsAb)的阳性率变化趋势。方法应用酶联免疫吸附试验(ELISA)法,对4149例儿童入托前进行HBsAb检测。结果0～2．0岁、2．1～3．0岁、3．1～4．0岁、4．1～5．0岁、5．0～6．0岁儿童乙型肝炎表面抗体阳性率分别为64．65％、68．64％、71．55％、74．21％、68．38％。经统计学分析,差异有统计学意义(x2=19．77,P<0．05)。结论新生儿注射乙型肝炎疫苗后,乙型肝炎表面抗体的阳性率随年龄的增高而增高,但到5～6岁后,乙型肝炎表面抗体的阳性率随年龄的增长而呈降低趋势。所以6岁以上儿童应进行注射乙型肝炎强化免疫。

Objective To discuss the preschool children after hepatitis B vaccines injected,the variation trend of hepatitis B surface antibody（HBsAb） ＇s positive rate , Methods 4149 preschool children＇s HBsAb were examined ,by means of enzyme linked immunosorbent assay（ELISA）, Results The HBsAb＇ s positive rate among the age from 0 - 2,2 1 - 3.0,3.1 - 4.0,4.1 -5.0, 5.0 - 6.0, for each age period, children＇ s HBsAb positive rates was 64. 65 %, 68.64 %, 71.5 5 % , 74.21%, 68.38 % respectively The statistical analysis showed that there was statistcal signicance（x^2 = 19.77,P〈0.05 ）. Conclusion The newhborn＇ s HBsAb＇ s positive rate increases as the age grown, after inject hepatitis B vaccines But after 5-6 yeara old, the HBsAb＇s positive rate shows a decrease trend. So the children older than 6 must be injected hepatitisB vaccines for immunity.