与早产儿视网膜病变自然退行有关因素的分析

Analysis of factors of spontaneous regression of prematurity retinopathy

目的将早产儿视网膜病变(ROP)自然退行组与ROP阈值病变组及视网膜脱离组的早产儿生后各因素进行分析,以寻找可能与ROP自然退行有关的因素。方法回顾性分析2002年7月至2004年10月检查的125例具有ROP的早产儿的临床资料,并进行统计学分析。结果自然退行组的平均出生体重及胎龄(1689.3g,31.7周)较ROP阈值病变组(1487g,30.6周)及视网膜脱离组(1418g,29.7周)大,具有显著统计学意义(P<0.01),ROP阈值病变组与视网膜脱离组之间的出生体重差异无显著统计学意义(P>0.05)。自然退行组矫正胎龄(37.1周)、阈值病变组(41.9周)及视网膜脱离组(74.6周)三者的诊断时间明显不同(P<0.01)。三组中性别(χ2分别为0.16、0.00004、0.2)无显著统计学意义。Logistic回归分析结果表明胎龄是ROP退行的影响因素。结论小胎龄可能与ROP不能自然退行有关。ROP预后与发现时间有关。

Objective Retinopathy of prematurity（ROP） is a main cause to lead to blindness in preterm infants. To screen the probably factors affecting its development is helpful for the control and treatment of ROP. Present work was to investigate the possible factors affecting spontaneous regression of retinopathy of prematurity （ ROP）. Methods The clinic data of ROP from 125 pretcrm infants diagnosed at Peking University People＇ s Hospital from July 2002 to October 2004 were retrospectively analyzed. The infants were divided into following three groups ： spontaneous regressing ROP, threshold ROP and ROP with retinal detachment group. Various antenatal and preinatal risk factors were compared among the 3 groups. Results The average birth weight （1 689.3 g） and gestational age （ 31.7 weeks） in spontaneous regressing ROP group was statistieally greater than threshold ROP group （ 1 487 g,30.6 weeks）and ROP with retinal detachment group（ 1 418 g,29.7 weeks,P 〈0.01 ） ; there was no significant difference in birth weight between threshold ROP and ROP with retinal detachment groups （ P 〉 0. 05 ）. The corrective gestational age at diagnosing period showed significant differences among three groups （ 37. 1 weeks in spontaneous regressing ROP group,41.9 weeks in threshold ROP group and 74.6 weeks in ROP with retinal detachment group,respectively, P〈0.01）. No significant difference was found in gender among three groups. Logistic regression analysis indicated that gestational age was a critical factor of spontaneous regression of ROP. Conclusion Low gestational age is a key affecting factor for ROP advancement. The prognosis of ROP is related to the diagnosing age.