顺铂联合白细胞介素-Ⅱ置管治疗恶性胸腔积液的临床观察

Clinical evaluation of cisplatin and Interleukin-Ⅱ via catheterzation for malignant pleural effusion

目的观察顺铂联合白细胞介素-Ⅱ置管治疗恶性胸腔积液的疗效。方法本组共54例,其中肺癌32例,乳腺癌11例,食道癌5例,胃癌3例,肠癌3例。所有患者胸腔积液中均找到恶性细胞。经皮穿刺留置中心静脉导管行胸腔积液引流术后,胸腔内注入顺铂(DDP)60m g+白细胞介素-Ⅱ(IL-2)200万u。结果54例患者,CR 31例(57%),PR 13例(24%),NC 10例(19%),总有效率为81%。5例出现导管堵塞,经处理后再通。出现低热32例,胸痛24例,经对症处理后恢复。无气胸、肺水肿的发生。结论顺铂联合白细胞介素-Ⅱ置管治疗恶性胸腔积液,是简单、经济且效果较好的方法,能改善恶性肿瘤患者的生活质量,延长患者的生存期。

Objective：To evaluate the therapeutic efficacy of cisplatin and interleukin-Ⅱ via catheterization for malignant pleural effulion. Method ：Of the 54 patients,including 32 cases of lung cancer, 11 cases of breast cancer, 5 cases of esophageal cancer, 3 cases of gastric carcinoma, 3 cases of colorectal cancer. Malignant cells were found in their pleural effusion. They received catheterization in pleural cavity and were perfused with DDP 60mg andlL-2 200 万 u. Result：Of all the patients,a complete response was observed in 31 cases （57%） and a partial response in 13 cases（24%）,NC 10 cases （19%）,the overall response rate was 81 %. 5 of them had the catheter suffed up and became clear after given a treatment. There was low- grade fever in 32 patients and chest pain in 24 cases. They were treated with symptomatic medication and recovered later, no pneumothorax and pulmonary edema occurred. Conclusion ：Cisplantin and lnterleukin--Ⅱ via catheterization for malignant pleural effusion has good results and also simple and cheap. It can improve the patients＇ life quality and prolong survival.