纤维蛋白原功能在非霍杰金淋巴瘤测定的临床意义

Clinical Significance of Fibrinogen’s Function Determine in NHL

目的探讨纤维蛋白原(Fg)功能在非霍奇金淋巴瘤(NHL)测定的临床意义。方法用蕲蛇酶水解Fg,通过计算机自动检测系统测定以下项目:①纤维蛋白单体聚合反应速率(FMPS);②最大吸光度(AMAX);③Fg含量(Fg:c);④反应延滞时间(DT);⑤Fg功能指数(FMPS/AMAX,FI)。结果34例初诊及13例复发或未缓解NHL病人Fg功能检测结果:Fg浓度明显升高,与正常对照组比:(648±176)vs(270±84),P<0.01,(712±179)vs(270±84),P<0.01,均有显著性差异,功能增强,最大光密度增大,反应数率增大,反应延滞时间缩短,提示整个Fg功能增强,而复发或未缓解病人与初诊病人比:712±179/648±176,P<0.05,有统计学意义,表明复发或未缓解病人的Fg浓度及功能更高更强。结论Fg功能测定对指导临床NHL化疗及预后判断具有重要意义。

Objective To investigate prognostic clinical significance of fibrinogen＇s function determine in the NHL. Methods Acutulase hydrolyzed Fg was used by means of computer automatic detection system to detect ： （1） Fibrin monomer polymerization reaction speed （FMPS） ; （2） Maximum affracteion lominosity （AMAX） ; （3）Fg content（ Fg： c） ; （4）Reaction arrearage time （DT） ; （5） Function index （ FMPS/AMAX, FI）, Results Fibrinogen＇s content obvious ascend in the NHL of 34case of first visit to a doctor and13 case recrudescent either not revolving, fibrinogen＇s function were more strong and light density were more ac cretion and reaction speed were more fast and reaction arrearage time were more cut than that normal compare confluence. Conclusion Fibrinogen＇s function determines in the NHL of cure and prognostic deciding had important meaning.