期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脂蛋白脂酶与脑血管疾病

Lipoprotein Lipase and Cerebrovascular Disease
下载PDF
导出
摘要 研究发现,脂蛋白脂酶(LPL)在调节体内甘油三酯(TG)代谢和血浆脂蛋白(LDL、HDL-C、VLPL)水平方面发挥关键作用,且与脑卒中等有关。随着医学分子生物学技术的发展,在分子水平上探讨脑血管疾病的发生与发展越来越受到人们的关注。LPL基因多态性与动脉粥样硬化性疾病或卒中的关系成为近年来的研究热点。这些基因多态性与血脂异常、动脉粥样硬化和脑血管疾病之间存在一定的关系。 The studyes showed that lipoprotein lipase played a key role in regulating the metabolism of TG and the level of plasma lipoprotein, which is also related to brain shock. With the development of technique in medical molecular biology, studying the oecurence and development of cerebrovascular disease in molecular level is attracting more attention from researchers. The relationship between LPL gene polymorphism and atherosclerotic deseases or brain shock is the hot spot in recent years. These gene polymorphism maybe have some relation with lipid abnormal, atherosclerosis and cerebrovaseular diseases in some certain.
作者 林慧琼 李吕力
机构地区 广西壮族自治区人民医院神经内科
出处 《医学综述》 2006年第24期1483-1485,共3页 Medical Recapitulate
关键词 脑梗死 脂蛋白脂酶 基因多态性 基因表达调控 Cerebral infarction Lipoprotein lipase Gene polymorphism Gene expression and regulation
分类号 R743.33 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献20

  • 1Hamosh M,Hamosh P.Lipoprotein lipase:Its physiological and clinical significance[ J].Mol Aspects Med,1983,6(3):199-289.
  • 2Deeb SS,Peng RL.Structure of the human lipoprotein lipase gene[J].Biochemistry,1989,28(10):4131-4135.
  • 3Krapp A,Zhang H,Ginzinger D,et al.Structural features in lipoprotein lipase necessary for the mediation of lipoprotein uptake into cells[J].J Lipid Res,1995,36(11):2362-2373.
  • 4Murthy V,Julien P,Gagne C.Molecular pathobiology of the human lipoprotein lipase gene[ J].Pharmacol Ther,1996,70(2):101-135.
  • 5Hall S,Chu G,Miller G,et al.A common mutation in the lipoprotein lipase gene promoter,-93T/G,is associated with lower plasma triglyceride levels and increased promoter activity in vitro[ J ].Arterioscler Thromb Vasc Biol 1997,17(10):1969-1976.
  • 6Pasalic D,Sertic J,Kunovic B,et al.Lipoprotein lipase gene polymorphism and lipid profile in patients with hypertiglyceridemia[ J].Croat Med J,2001,42(5):517-522.
  • 7Razzaghi H,Aston CE,Hamman RF,et al.Genetic screening of the lipoprotein lipase gene for mutations associated with high triglyceride/lowHDL-cholesterol levels[ J ].Hum Genet,2000,107 (3):257-267.
  • 8Oka K,Tkalcevic GT,Nakano T,et al.Structure and polymorphic map of human lipoprotein lipase gene.Structure and polymorphic map of human lipoprotein lipase gene[ J].Biochiin Biophys Acta,1990,1049(1):21-26.
  • 9Murano T,Miyashita Y,Itoh Y,et al.Incidence of lipoprotein lipase genotype for premature termination codon (Ser447-Ter) in Japanese,and association with dyslipoproteinemia[ J].Clin Chim Acta,1998,275(2):205-213.
  • 10Hoffer MJ,Bredie SJ,Snieder H,et al.Gender-related association between the -93T--》 G/D9N haplotype of the lipoprotein lipase gene and elevated lipid levels in familial combined hyperlipidemia[ J].Atherosclerosis,1998,138(1):91-99.

二级参考文献10

  • 1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33022
  • 2Goldberg IJ. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis[J]. J Lipid Res, 1996, 37: 693-707.
  • 3Shimo-Nakanishi Y, Urable T, Hattori N, et al. Polymorphism of the lipoprotein lipase gene and risk of atherothrombotic cerebral infarction in the Japanese[J] .Stroke,2001,32:1481-1486.
  • 4Mychykangas L, Polikoski T, Sulkava R, et al. Association of lipoprotein lipase Ser447Ter polymorphism with brain infarction: a population-based neuropathological study [ J ]. Ann Med, 2001,33 :486-492.
  • 5Xin X, Srinivasan SR, Chen W, et al. Interaction effect of Serine447Stop variant of the lipoprotein lipase gene and C-514T variant of the hepatic lipase gene on senma triglycefide levels in young adults: The Bogalusa Heart Study [ J ]. Metabolism, 2003,52: 1337-1342.
  • 6Lindenstrom E, Bogsen G, Nyboe J, et al. Influence of total cholesterol,high density lipoprotein cholesterol, and triglycerides on risk of cerebrovascular disease: the Copenhagen City Heart Study published erratum appears in BMJ[J]. BMJ, 1994,309:11-15.
  • 7Sacco RL, Benson RT, Kargman DE, et al. High-density lipoprotein cholesterol and ischemic stroke in the elderly: the Noahem Manhattan Stroke Study[J] .JAMA, 2001, 285:2729-2735.
  • 8Clee SM, Loubser O,Collins J, et al. The LPL S447DX Csnp is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease[J]. Clin Genet, 2001,60:293-300.
  • 9Sass C, Hwenard H, Gerard S, et al. Lipoprotein lipase (C/G)447 polymorphism and blood pressure in the Stanislas Cohort[ J]. J Hypertens, 2000,18:1775-1781.
  • 10Baum L, Chen L, Masliah E, et al. Lipoprotein lipase nmtations and Alzheimer' s disease[J]. Am J Med Genet, 1999,88:136-139.

共引文献2

医学综述
2006年 第24期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部