大Y染色体对体外受精与胚胎移植的影响

Big Y Chromosome Not Significantly Influences Outcomes of in vitro Fertilization and Embryo Transfer

目的:探讨在体外受精与胚胎移植中大Y染色体对其受精方式及结局的影响。方法:对进行IVF/ICSI-ET助孕中的113例患者(共127个周期治疗)进行前瞻性研究,大Y染色体组(A组)共56个治疗周期,染色体正常组(B组)共71个治疗周期。结果:A、B两组间受精率、卵裂率、胚胎质量、临床妊娠率、种植率、流产率、异位妊娠率、死婴出生率、畸形率、男婴出生比例及女婴出生比例,差异均无显著性(P>0.05)。结论:大Y染色体对胚胎发育及近期妊娠结局无明显影响。

Objective： To evaluate the influence of big Y chromosome on the outcomes of in vitro fertilization and embryo transfer. Methods ： Data of 127 cycles of IVF/ICSI-ET, performed in our Reproductive Medicine Center from March 2001 to June 2003 were analyzed. The patients were divided into two groups according to the length of chromosome： Group A, 56 cycles with big Y chromosome and Group B, 71cycles with normal karyotype. Results： No significant difference was observed in the quality of embryos and in the rates of fertilization, cleavage, clinical pregnancy, implantation, miscarriage, ectopic pregnancy, dead infant delivery, malformation, baby boy delivery and baby girl delivery between the two groups. Conclusion ： Big Y chromosome has no significant influence on the development of embryos and the outcome of pregnancy.