胃癌组织学特征的演变规律的初步探讨

The initial study on evolution of pathological characteristics of gastric carcinoma.

目的了解胃癌的组织学变化规律。方法回顾性分析1985至2005年间我科开展临床普查人群中所发现胃癌病例的组织学特征。结果156例胃癌中,位于粘膜和粘膜下层者以及肌层者均以高分化腺癌为主,分别为62例(92.75%)和14例(73.68%),而浸及浆膜层者以低分化腺癌为主13例(39.39%),腺癌分化程度与癌肿浸润的深度具有相关性(相关系数ρs=0.6125,P=0.0000);而癌肿的部位与组织学无明确的相关性。结论胃癌形成后组织学特征仍在不断变化,其总体趋势为高度恶性向低度恶性、高分化向低分化发展。

Objective To learn the regular histological pattern of progress in gastric carcinoma（ GC）. Methods The data of patients who suffered gastric carcinoma were reicwcd.The patients were diagnosed between 1985 and 2005 when a clinic screening was carried out. Results Among 156 patients,92.75 % of lesions limited to the mucosa and submucosa propria differentiated well, 73.68% of lesions limited to muscularis propria had media differentiation, and 39.39 % of lesions i,nmerge to serous membrane differentiated poor, The grade of differentiation was correlated with the soakage of gastric carcinoma（ ρs = 0.6152, P = 0.0000）. Conclusion The changes of histologic characteristics was accompanied with gastric carcinoma progress,and the mainly change tendency of diffcrcntion is from well to prior.