老年人T淋巴细胞亚群变化的相关因素分析

An Analysis of the Correlative Factors of T Lymphocyte Cell Subsets in the Aged

目的:探讨老年人T淋巴细胞亚群变化的相关因素。方法:对70例患者(老年组32例,非老年组38例)应用流式细胞仪测定T淋巴细胞亚群CD3、CD4、CD8、CD4/CD8,并分别进行比较。结果:老年组CD3明显低于非老年组(P<0.01),CD4、CD8、CD4/CD8无明显差异。对32例老年人根据其营养状况、生活能力以及是否伴有感染性疾病,分别分组比较T淋巴细胞亚群变化情况,均无明显差异。结论:老年人细胞免疫功能下降主要与年龄增长有关,与营养状况好坏、生活能否自理以及是否伴有感染性疾病关系不大。

Objective：To investigate the correlative factors of T lymphocyte cell subsets in the aged. Methods：We measured the percentages of T lymphocyte cell subsets by flow cytometer in 70 patients （32 cases from the aged group, 38 cases from the contral group）. Results ： The CD3 of the aged group was obviously lower than that of the eontral group （ P 〈0.01 ） ,There was no difference in CD4.CD8.CD4/CD8 between aged group and the contral group. Conclusion ：The decline in immunological function of the aged relates mainly to the age and has little to do with nutritive situation, viability and the disease of infection.