高压无针注射器痂下注射抗生素防治烧伤创面感染实验研究

ANTIBIOTIC INJECTION WITH DERMO-JET FOR PREVENTING BURN WOUND INFECTION IN RATE

实验用大鼠30支，动物烫伤后立即创面接种绿脓杆菌225株1ml，随机分为痴注组、腹腔注射组和对照组，24小时后用高压无外注射器和空计分别经痴下和腹腔注射抗生素．结果显示：痴往组，痴下组织菌量、局部感染程度、心血培养和死亡率均低于腹腔注射组和对照组．表明用高压无针注射器痴了注射抗生素能发挥满意抑、杀菌效果，对防治烧伤创面感染有良好的临床应用前景和推广使用价值。

Thirty rats were burned experimentally and applied with 109 CFU/ml of pseudomonas aeruginosastrain 225 1ml. Then randomly divided into three groups: injection with Dermo-Jet in subeschar tis-suesi injection with syringe intraperitoneally and control group. Antibiotic was given at intervals oftwelve hours 24 hours after inoculation of psedomonas aeruginosa and lasted twenty days. Bacterialcounts of subeschar tissue, histopathologic study of the wound, heart blood culture and mortality rateare chosen as laboratory criteria.Results of the study show that in ' Dermo-Jet' group becterial counts of subeschar tissue,histopathologic study of the wound and positive rate of heart blood culture are less than in bthergroups,and the mortality rate is zero. AIl indicate that injection with Dermo-Jet has a strong antibacte-rial effect and is a good method for preventing burn wound infection in clinic prectice.