镁和普罗帕酮治疗妊娠期阵发性室上性心动过速的对照研究

A STUDY ON THE EFFECT OF MAGNESIUM VERSUS PROPAFENONE ON GESTATIONAL PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA

镁剂可用于治疗各种心律失常，但很少用于治疗妊娠期心律失常．本文采用随机单育研究，普罗帕酮（35mg静脉注射，继以0．5mg／分静滴维持）作为对照，评价静脉注射硫酸误（2．5g静注，继以20mg/分静滴维持）治疗妊娠期阵发性室上性心动过速（发作超过30分钟）的安全性和有效性．结果：镁组7例中5例（71％）转复窦性心律，镁组无副作用．普罗帕附组1例出现窦性心动过缓．显示镁剂是治疗妊娠期阵发性室上性心动过这有效而安全的药物．

Magnesium has previously been used in the treatment of various arrhythmias, but has seldom ifever been used in the treatment of gestational arrhythmias. In a single-blind study, the efficacy andsafety of intravenous magnesium sulfate (bolus doses of 2.5g followed by infusion of 20mg/min) versus propafenone (bolus doses of 35 mg followed by infusion of 0. 5mg/min) were evaluated in 13 ges-tational paroxysmal supraventricular tachycardias(onset more than 30 minutes). Five (71 % ) of thepatients receiving magnesium (n = 7) converted to sinus rhythm (NS) within 3O minutes, and five(83 % ) of the patients receiving propafenone (n = 6) converted to sinus rhythm(NS). No side effectswere observed during magnesium infusion, whereas one patient receiving propafenone had sinusbradycardia. Magnesium appears to be an effective and safe durg for the treatment of gestationalparoxysmal supraventricuIar tachycardia.