摘要
石杉碱甲（双益平）：一种有望治疗早老性痴呆症的药物唐希灿（中国科学院上海药物研究所药理室、新药研究国家重点实验室，上海２０００３１，中国）关键词石杉碱甲；双益平；胆碱酯酶抑制剂；记忆；乙酰胆碱；认知障碍；药物动力学；他克林；毒扁豆碱；阿耳茨海默病Ｈｕ...
IM:
To detect DNA damage caused by fotemustine (Fot). METHODS: DNA
damage in HL60 cells was evaluated by modified alkaline elution
technique. DNA interstrand crosslink (ISC) and DNA protein
crosslink (DPC) were determined. Carmustine (Car) was used as
control. Drug treatment time was 1 h . RESULTS: After treatment with
Fot 300 μmol·L -1 , ISC and DPC index were 5 4 and 6 1 at 6
h, 2 7 and 1 2 at 12 h, respectively. ISC reached the maximum at
about 6 h. For Fot 100 μmol·L -1 , ISC and DPC index at ISC
peak time were 2 1±0 9 and 3 55±0 23, 5 0±0 5 and 7 7±1 1
for Car 100 μmol·L -1 , respectively. Single strand break (SSB)
was induced by Fot. CONCLUSION: Fot caused HL60 cell DNA ISC, DPC,
and SSB. ISC was formed more quickly by Fot than that by Car.
出处
《中国药理学报》
CSCD
1996年第6期481-484,共4页
Acta Pharmacologica Sinica
关键词
石杉碱甲
双益平
记忆
药物动力学
早老性痴呆
huperzine A
Shuangyiping
cholinesterase inhibitors
memory
acetylcholine
cognition disorders
pharmaco￣kinetics
tacrine
physostigmine
Alzheimers disease
