摘要
卡托普利对主动脉平滑肌细胞增殖的影响熊一力1,赵华月(同济医科大学同济医院内科,武汉430030,中国)关键词卡托普利;胸主动脉;血管平滑肌;培养的细胞;高脂血清;胸苷;6酮前列腺素F1α;环腺苷一磷酸;丙二醛;血纤维蛋白溶酶原失活剂目的:观察卡托...
IM: To study the
effect of captopril (Cap) on proliferation of smooth muscle cells
(SMC). MATHODS: Proliferation of cultured porcine aortic SMC was
promoted by hyperlipidemic sera (HLS). RESULTS: Cap (0 2 mg·L -1
) remark ̄ably reduced thymidine (TdR) incorpora ̄tion, inhibited
DNA synthesis and proliferation of SMC, and lessened morphological
changes caused by HLS. After administration of Cap, malondial ̄dehyde
(MDA) content and plasminogen activator inhibitor (PAI) activity were
reduced, 6 keto PGF 1α and cAMP contents were obviously
increased ( P <0 05-0 01) . CON ̄CLU ̄SION: Cap inhibited the
proliferation of SMC, associated with MDA, PAI, 6 keto PGF 1α
and cAMP.
出处
《中国药理学报》
CSCD
1996年第6期503-506,共4页
Acta Pharmacologica Sinica
关键词
卡托普利
胸主动脉
血管平滑肌
胸苷
前列腺素
captopril
thoracic aorta
vascular smooth muscle
cultured
cells
hyperlipidemia
thymidine
6 ketoprostaglandin F1 alpha
cyclic AMP
malondialdehyde
plasminogen inactivators