卡托普利对主动脉平滑肌细胞增殖的影响

Effect of captopril on proliferation of aortic smooth muscle cells

卡托普利对主动脉平滑肌细胞增殖的影响熊一力１，赵华月（同济医科大学同济医院内科，武汉４３００３０，中国）关键词卡托普利；胸主动脉；血管平滑肌；培养的细胞；高脂血清；胸苷；６酮前列腺素Ｆ１α；环腺苷一磷酸；丙二醛；血纤维蛋白溶酶原失活剂目的：观察卡托...

IM: To study the effect of captopril (Cap) on proliferation of smooth muscle cells (SMC). MATHODS: Proliferation of cultured porcine aortic SMC was promoted by hyperlipidemic sera (HLS). RESULTS: Cap (0 2 mg·L -1 ) remark￣ably reduced thymidine (TdR) incorpora￣tion, inhibited DNA synthesis and proliferation of SMC, and lessened morphological changes caused by HLS. After administration of Cap, malondial￣dehyde (MDA) content and plasminogen activator inhibitor (PAI) activity were reduced, 6 keto PGF 1α and cAMP contents were obviously increased ( P <0 05-0 01) . CON￣CLU￣SION: Cap inhibited the proliferation of SMC, associated with MDA, PAI, 6 keto PGF 1α and cAMP.