摘要
钾通道开放剂对培养兔主动脉平滑肌细胞增殖的抑制作用１史道华２，郭兆贵（湖南医科大学药理研究室，长沙４１００７８，中国）关键词血管平滑肌；胸主动脉；培养的细胞；细胞分裂；苯福林；钾通道目的：探讨吡那地尔（Ｐｉｎ），尼可地尔（Ｎｉｃ），ＲＰ４９３５６（Ｒ...
IM: To study the
effects of pinacidil (Pin), nicorandil (Nic), RP 49356 (RP), and
lemakalim (Lem) on phenylephrine (PE) induced prolifera￣tion of
cultured rabbit aortic smooth muscle cells (ASMC). METHODS: The
thymidine incorporation into DNA and number of ASMC were measured.
RESULTS: Thymidine uptake induced by PE was markedly inhibited by
Pin, Nic, RP, and Lem (0 1-10 μmol·L -1 ). Only RP inhibited
thymidine uptake without PE pretreatment. Cell growth induced by PE
was completely inhibited by Pin. CONCLUSION: Pin, Nic, RP, and Lem
showed potent anti￣proliferation of ASMC.
出处
《中国药理学报》
CSCD
1996年第6期513-515,共3页
Acta Pharmacologica Sinica
基金
the
Foundation
of
Scientific
Commitee
of
Hunan
Province
关键词
血管平滑肌
胸主动脉
细胞分裂
苯福林
钾通道
vascular smooth muscle
thoracic aorta
cultured cells
cell
division
phenylephrine
potassium channels
