摘要
奎尼丁和奎宁对人和大鼠肝微粒体氧化酶的抑制作用１涂植光，赵梁立２（重庆医科大学临床生化教研室，２药理教研室，重庆６３００４６，中国）关键词奎尼丁；奎宁；肝微粒体；遗传药理学；丁呋洛尔；烃基香豆素脱烃基酶；芳基烃羟化酶类目的：比较奎尼丁和奎宁对人和大鼠...
IM: To compare the inhibitory
effects of quinidine and quinine on liver microsome bufuralol 1′
hydroxylase (BH), aryl hydrocarbon hydroxyl￣ase (AHH), and 7
ethoxycoumarin O deethyl￣ase (ED) activities in man and rat.
METHODS: A normal phase HPLC and the fluorescence spectrometry were
used to assay the enzyme activities. RESULTS: Both quinidine and
quinine produced a concentration dependent inhibition to liver
microsome BH, AHH, and ED in man and rat. Their median inhibitory
concentrations (IC 50 ) on liver microsome BH, AHH, and ED low
and high affinity phases were 0 2, 378, 2952, and >5000 μmol·L
-1 for quinine in man, 290, 613, 1465, 1595, μmol·L -1 for
quinidine in rat; 29, 207, 808, and >5000 μmol·L -1 for quinine
in man, and 31, 54, 597, and 2508 μmol·L -1 for quinine in
rat, respectively. CONCLUSION: Quinidine is a species and stereo
selective potent inhibitor to human liver microsome BH.
出处
《中国药理学报》
CSCD
1996年第6期541-544,共4页
Acta Pharmacologica Sinica
基金
the
Youth
Funds
of
State
Educational
Commission
关键词
奎尼丁
奎宁
肝微粒体
遗传药理学
氧化酶
quinidine
quinine
liver micro￣somes
pharmacogenetics
bufuralol
7 alkoxy￣cou￣marin O dealkylase
aryl hydrocarbon
hydroxylases
