N,N'-双(2-吡啶甲酰胺)-1,2-乙烷双核稀土配合物的合成及与DNA的相互作用

Synthesis of binuclear rare earth complexes of N,N'-bis(2-pyri-dinecarboxamide)-1,2-ethane and study on their Interaction with deoxyribonucleic acid

合成了十种稀土元素（La、Ce、Pr、Nd、Dy、Ho、Er、Tm、Yb、Lu）与N，N＇双（2-吡啶甲酰胺）-1，2-乙烷（H2L）的配合物。经元素分析、热重分析、摩尔电导、像、UV及^1HNMR表征，确定配合物的组成为：[Ln2（H2L）3（NO3）2]（NO3）4·nH2O，（其中Ln=La、Ce、Pr、Nd，n=0；Ln=Dy、Ho、Er、Tm、Yb、Lu，n=3），其中配体H2L中酰胺羰基氧和吡啶氮分别与稀土离子配位，硝酸根为双齿配体。通过光谱法对配合物与脱氧核糖核酸（DNA）的作用进行了初步研究，得到配合物与DNA的结合常数为1．6×10^4-2．3×10^4。

Ten binuclear rare earth complexes of N, N＇-Bis（2-pyridinecarboxamide）-1, 2-ethane have been synthesized and characterized by elemental analysis, conductivity measurement, thermal studies, IR and electronic spectra. The composition of the ten complexes is [ Ln2 （ H2L） 3 （ NO3 ） 2] （ NO3 ） 4. nH2O, （ Ln= La, Ce. Pr. Nd, n= 0; Ln= Dy, Ho. Er. Tm, Yb, Lu, n= 3 ）. Experimental results indicate that coordinating of the oxygen of carbonyl and the nitrogen of pyridyl to Ln（ Ⅲ ） and the NO3 shows bidentate coordination. Meanwhile the interaction between the complexes and deoxyribonucleic acid has been studied by spectral methods. The binding constant Kb obtained is 1.6 × 10^4 -2. 3 × 10^4. Spectral results indicate that the ten pyridinecarboxamide complexes bind to DNA mainly through the intercalation mode.