群体反应性抗体与移植肾功能延迟恢复的关系

Correlation between panel recative antibody and delayed graft function

目的探讨群体反应性抗体(PRA)与移植肾功能延迟恢复(DGF)的关系。方法将PRA>10.0%的肾移植51例作为PRA阳性组(实验组),并以同期PRA≤10.0%的肾移植161例作为PRA阴性组(对照组),观察两组间术后DGF发生率。结果PRA阳性组除去超急性排斥反应(HAR)4例外27例术后并发DGF(57.4%),PRA阴性组除去2例HAR外有15例并发DGF(9.4%),两组DGF发生率比较差异有显著性(P<0.05)。结论PRA阳性是DGF发生的重要因素。

[Objective] To investigate the correlation between PRA and DGF. [Methods] Fifty-one renal recipients with PRA over 10% served as experiment group （PRA positive）. One hundred and sixty-one patients undergoing renal transplantation with PRA less than 10% were harvested as control group （PRA negative）. The rate of DGF between the two group was observed after operation. [Results] The rate of DGF was 57.4% in experiment group except for two cases of hyper acute rejection （HAR）, while in the control group, the rate was only 9.4%. There were significant differences between the two group on the probability of DGF （P 〈0.05%）. [Conclusion] PRA positive may play a very important role in the oeeurrence of DGF.