血清新蝶呤检测对登革病毒感染的早期评估

Detection of Serum Neopterin for Early Assessment of Dengue Virus Infection

目的探讨血清新蝶呤检测在登革病毒感染早期诊断中的潜在应用价值。方法检测110例登革热(DF)病人血中新蝶呤的含量,将其与50份水痘病人和40份流感病人血中新蝶呤的含量进行比较,155份来自健康献血员的血清作为对照。结果急性期登革热病人血中新蝶呤的平均含量为48.2nmol/L,高于水痘病人、流感病人和健康对照者血中的平均含量(分别为36.3nmol/L、18.8nmol/L和6.7nmol/L,P<0.001)。在已经确诊的登革热病人中,症状出现第一天即可检测到血中新蝶呤含量升高,且在病程第四天升至最大值54.3nmol/L。血中新蝶呤含量升高的水平与热程相关,因而可以用来确定病程长短。结论登革热病人血中新蝶呤含量较健康对照者以及其它病毒感染者显著升高(P<0.001),可以作为早期确定登革热严重程度的指标。

Objective To discuss the potential value of neopterin in early prognostic information of dengue virus infection. Method Neopterin concentrations were determined in serum samples from 110 severe acute dengue fever（DF） patients. The neoptefin levels were compared with those in 50 respiratory syndrome measles and 40 influenza patients; 155 healthy blood donors served as controls. Result In sera of acute DF patients mean neopterin concentration was 48.2 nmol/L, higher than that in patients with measles （36.3 nmol/L） and influenza （18.8 nmol/L） and in control group （6.7 nmol/L; P 〈 0.001）. In the patients with confirmed DF, an early neoptefin elevation was detected on the first day after the onset of symptoms and rose to a maximum level of 54.3 nmol/L 4 days after the onset. Higher increase of neopterin level in DF patients was associated with longer duration of fever and thus predicted the clinical course of the disease. Conclusion Neopterin concentrations, showing significantly higher in DF patients than that in control group and people with other viral infections （P 〈 0.001 ） and may allow early assessment of the severity of DF.