B超对当归补血汤复方及单味药治疗兔血吸虫病肝纤维化的效果评价

Evaluation of Treatment against Hepatic Fibrosis of Schistosomiasis with Dangguibuxue Decoction or Single Herb Extract by Ultrasonography

目的探讨B超对当归补血汤复方及单味药治疗兔血吸虫病肝纤维化效果评价的价值。方法建立家兔血吸虫性肝纤维化模型,并将实验动物分成四组,其中三组分别用从当归、黄芪、当归加黄芪中提取的口服液结合吡喹酮进行治疗,对照组只给予吡喹酮进行病原学治疗。再用B超声像图评估当归、黄芪和当归补血汤治疗血吸虫病肝纤维化的效果。结果治疗A组(当归)、B组(黄芪)和C组(当归补血汤)均对兔血吸虫病肝纤维化有一定的疗效,其中C组(当归补血汤)的疗效最好,治疗前后肝长径、厚径、横径、PV内径测值均有显著性意义(P<0.05)。结论当归补血汤对血吸虫病肝纤维化的治疗作用优于单味药当归或黄芪。

Objective To evaluate the treatment effects on hepatic fibrosis of schistosomiasis with Dangguibuxue decoction or single herb extract of Danggui （Angelica sinensis）, Huangqi （Radix astragalus）, by uhrasonography. Method Hepatic fibrosis model of schistosomiasis was set up on rabbits and divided them into 4 groups. The three experimental group＇s rabbits were treated with Priziquantel combined with the extract of Angelica sinensis, Radix astragalus, or Angelica sinensis and Radix astragalus, while the control group＇s rabbits were treated only with Priziquantel. And then the effects of treatment on the four groups were evaluated by B-uhrasonography. Result All of the experimental groups have good treatment effects on hepatic fibrosis of schistosomiasis. And the group treated with extract of Angelica sinensis and Radix astragalus is the best. It showed significant differences in length, thickness, and the cross diameter of liver and portal vein inner diameter before and after treatment （P 〈 0.05）. Conclusion The treatment effect of complex dangguibuxue decoction is better than single herb extract of Angelica sinensis or Radix astragalus.