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肥胖相关性肾小球病发病机制的研究进展

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摘要 1997年世界卫生组织确定肥胖是一种疾病，近20年其发病率明显升高。肥胖不仅是高血压、动脉粥样硬化病及糖尿病的高危因素，而且可以导致肾损害。1974年Weisinger等首次报告严重肥胖患者能出现大量蛋白尿，此其后此病被命名为“肥胖相关性肾小球病”（obesity-related glomerulopathy，ORG）。病理检查ORG可分成两型，仅表现为肾小球肥大者称为“肥胖相关性肾小球肥大症”（obesity-associated glomerulomegaly，OB-GM），表现为肾小球肥大及局灶节段性肾小球硬化者称为“肥胖相关性局灶节段性肾小球硬化”（obesity-associated focal and segmental glomerulosclerosis，OB-FSGS）。
作者 沈水娟（综述） 谌贻璞（审校） 杨敏（审校）
机构地区 中国协和医科大学研究生院 卫生部中日友好医院肾病中心
出处 《临床肾脏病杂志》 2006年第6期284-286,共3页 Journal Of Clinical Nephrology
关键词 肥胖患者 肾小球病 病发病机制 肾小球肥大 肾小球硬化 局灶节段性 世界卫生组织 大量蛋白尿
分类号 R472.9 [医药卫生—护理学]
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参考文献38

  • 1Weisinger JR, Kempson RL, Eldridge FL, et al. The nephrotic syndrome:a complication of massive obesity. Ann Intern Med, 1974, 81 : 440-447.
  • 2董葆,陈文,程虹,李安,谌贻璞,邹万忠.肥胖相关性局灶节段性肾小球硬化症临床与病理表现[J].中华肾脏病杂志,2002,18(6):389-392. 被引量：32
  • 3Kambham N, Markowitz GS, Valeri AM, et al. Obesity-related glomerulopathy: An emerging epidemic. Kidney Int,2001, 59: 1498-1509.
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二级参考文献14

  • 1Weisinger JR, Kempson RL, Eldridge FL, et al. The nephrotic syndrome: a complication of massive obesity. Ann Intern Med,1974,81: 440-447.
  • 2Praga M, Hernandez E, Morales E, et al. Clinical features and long-term outcome of obesity-associated focal segmental glomerulosclerosis. Nephrol Dial Transplant, 2001, 16:1790-1798.
  • 3Kambham N, Markowitz GS, Valeri AM, et al. Obesity-related glomerulopathy: An emerging epidemic. Kidney Int, 2001, 59:1498 - 1509.
  • 4Adelman R. Obesity and renal disease. Curr Opin Nephrol Hyperten, 2002, 11: 331-335.
  • 5Praga M, Borstein B, Andres A, et al. Nephrotic proteinuria without hypoalbmninemia: clinical characteristics and response to angiotensin-converting enzyme inhibition. Am J Kidney Dis,1991, 17: 330.
  • 6Praga M, Morales E, Herrero JC, et al. Absence of hypoalbuminemaia despite massive proteinuria in focal segmental glomerulosclerosis secondary to hyperfiltrafion. Am J Kidney Dis, 1999, 33: 52-58.
  • 7Chagnac A, Weinstein T, Korzets A, et al. Glomerular hemodynamics in severe obesity. Am J Physiol Renal Physiol, 2000,F817-F822.
  • 8Anderson PW, Zhang XY, Tiaa J, et al. Insulin and angiotensin Ⅱ are additive in stimulating TGF-beta 1 and matrix mRNAs in mesangial cells. Kidney Int, 1996, 50: 745-753.
  • 9Fujiwara K, Hayashi K, Ozawa Y, et al. Renal protective effect of troglitazone in Wistar fatty rats. Metabolism, 2000, 49:1361-1364.
  • 10Wolf G, Hamann A, Han DC, et al. Leptin stimulates proliferation and TGF-beta expression in renal glomerular endothelial cells. Kidney Int, 1999,56: 860-872.

共引文献31

临床肾脏病杂志
2006年 第6期

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