对骨的良性纤维组织细胞瘤及相关病变的分析

Analysis of benign bone fibrous histiocytoma and related diseases

目的探讨骨BFH的特殊变化与生物学行为的关系,以与MFH、NOF、MFD鉴别。方法常规HE染色和免疫组织化学染色,检测肿瘤组织P53、PCNA、CD34的表达;分析组织学、影像学及临床指标与生物学行为相关性的特点。结果BFH瘤灶与周围正常组织之间的微细变化的组织病理学与影像诊断学指标,复发性、年龄、病灶范围等临床指标,与MFH有明显的同一趋向性,而与NOF、MFD则有明显的差异性。结论瘤灶与周围正常组织之间的微细变化,在判断肿瘤的生物学行为上具有重要意义,是BFH与NOF、MFD鉴别诊断的主要指标。BFH是既不同于MFH又不同于NOF、MFD的一种独立病变。

Objective To investigate the changes of bone benign fibroushistiocytom（BFH） and its biological behavior and to identify it from malignant fibrous histiocytoma （MFH）, nonossifying fibroma （NOF） and metaphyseal fibrous defect. Methods Common HE and immunohistochemical staining were used to detect the expression of P53, PCNA and CD34. The characters of histology, imaging, clinical manifestation and biological behavior were analyzed. Results BFH was obvious similar with MFH at the cellular changes of histology, imaging diagnostic indexes, recurrence rate, age of onset and disease focus. BFH was different from NOF and MFD significantly. Conclusions The change of relation between the disease locus and the surrounding normal tissue was very important at judging the biological behavior of tumors. It＇ s the key index to identify BFH from NOF and MFD. BFH is an independent disease and different from MFH and NOF and MFD.