摘要
目的:研究商陆对阿霉素肾病大鼠肾组织一氧化氮(NO)的影响。方法:经大鼠尾静脉分次注射阿霉素合计7.5mg/kg制备肾病模型,分别灌以商陆粗提物4g/kg.d和1g/kg.d或强的松16mg/kg.d,连续2周,观察各组动物肾组织NO的改变。结果:商陆粗提物对阿霉素肾病模型大鼠具有减少尿蛋白、降低肾组织内NO浓度作用。结论:商陆对阿霉素肾病具有治疗作用,其治疗作用可能与降低肾组织内NO浓度有关。
Objective ：To observes the effects of phytolaccae on nitrogen monoxide （NO） in kidney tissue of adriamicin - induced nephropathy rat. Method： Male SD rat nephropathy was induced by multiple injection of adriamicin to vena caudalis, with total dose 7.5mg/kg. The rats were fed with crude extract from phytolaccae（4g/kg. d or lg/kg.d ） or prednisone （ 16mg/kg. d） for 2 weeks ,and then their kidney tissue NO measured. Result ：The rats＇urine protein , kidney tissue NO were decreased in both phytolaccae and prednisone groups （P 〈0.05）. Conclusion： The phytolaccae has therapeutical effects to nephropathy, and it may be related t.9 the reduction of kidney tissue NO.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2006年第6期49-50,共2页
Pharmacology and Clinics of Chinese Materia Medica
关键词
商陆
阿霉素
肾病
一氧化氮
Phytolaccae
adriamicin - induced nephropathy
NO
